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公开(公告)号：US20100292437A1
公开(公告)日：2010-11-18
申请号：US12322801
申请日：2009-02-06
IPC分类号： C07K7/00
摘要： The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The polypeptides of the present invention are most preferably between 12 and 13 amino acid residues in length and a mass of about 1249. The present invention also relates to a method of treating obesity by administering to obese subjects an effective amount of the polypeptides of the present invention.
摘要翻译： 本发明涉及从熊衍生物分离物获得的多肽，其可用于抑制食欲。 本发明的多肽最优选长度为12至13个氨基酸残基且质量约为1249.本发明还涉及通过向肥胖受试者施用有效量的本发明多肽来治疗肥胖症的方法 发明。
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公开(公告)号：US07060300B2
公开(公告)日：2006-06-13
申请号：US10841710
申请日：2004-05-07
摘要： A bear derived isolate found in denning black bears or black bears from which food has been withheld for at least two weeks when injected into another mammal produces reduced heart rate, reduced respiratory rate, reduced temperature, and a wakeful tranquility not unlike the phenomena of the denning black bear. The isolate is taken from either the serum or urine of such denning bear. The method of the invention involves the steps of fractionating the serum or urine of a denning black bear to produce fractions of varying potency.
摘要翻译： 在注射到另一种哺乳动物时，至少两周内禁食黑色熊或黑熊的熊衍生的分离物发现降低的心率，降低的呼吸频率，降低的温度和醒觉的宁静与不同于 诋毁黑熊 分离物取自这种剔骨的血清或尿液。 本发明的方法包括分离脱色黑熊的血清或尿液以产生不同效力的级分的步骤。
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公开(公告)号：US07544662B2
公开(公告)日：2009-06-09
申请号：US11198768
申请日：2005-08-05
IPC分类号： A61K38/00
摘要： The present invention relates to polypeptides obtained from bear derivative isolate which are useful in suppressing appetite. The polypeptides of the present invention are most preferably between 12 and 13 amino acid residues in length and a mass of about 1249. The present invention also relates to a method of treating obesity by administering to obese subjects an effective amount of the polypeptides of the present invention.
摘要翻译： 本发明涉及从熊衍生物分离物获得的多肽，其可用于抑制食欲。 本发明的多肽最优选长度为12至13个氨基酸残基且质量约为1249.本发明还涉及通过向肥胖受试者施用有效量的本发明多肽来治疗肥胖症的方法 发明。
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公开(公告)号：US06855337B1
公开(公告)日：2005-02-15
申请号：US10232880
申请日：2002-08-30
摘要： A bear derived isolate found in denning black bears or black bears from which food has been withheld for at least two weeks when injected into another mammal produces reduced heart rate, reduced respiratory rate, reduced temperature, and a wakeful tranquility not unlike the phenomena of the denning black bear. The isolate is taken from either the serum or urine of such denning bear. The method of the invention involves the steps of fractionating the serum or urine of a denning black bear to produce fractions of varying potency.
摘要翻译： 在注射到另一种哺乳动物时，至少两周内禁食黑色熊或黑熊的熊衍生的分离物发现降低的心率，降低的呼吸频率，降低的温度和醒觉的宁静与不同于 诋毁黑熊 分离物取自这种剔骨的血清或尿液。 本发明的方法包括分离脱色黑熊的血清或尿液以产生不同效力的级分的步骤。
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