公开(公告)号：US08789254B2

公开(公告)日：2014-07-29

申请号：US13007692

申请日：2011-01-17

申请人： Ramesh S. Minisandram ,  Richard L. Kennedy ,  Robin M. Forbes Jones

发明人： Ramesh S. Minisandram ,  Richard L. Kennedy ,  Robin M. Forbes Jones

IPC分类号： B23P17/00

CPC分类号： B21J3/00 ,  B21C23/32 ,  B21J1/06 ,  C21D7/06 ,  C21D8/0284 ,  C22C19/00 ,  C22C19/03 ,  Y10T29/49812 ,  Y10T29/49885 ,  Y10T29/49888 ,  Y10T29/4998 ,  Y10T29/49982 ,  Y10T29/49986 ,  Y10T428/1317

摘要： A method of processing an alloy ingot or other alloy workpiece to reduce thermal cracking may generally comprise depositing a glass material onto at least a portion of a surface of a workpiece, and heating the glass material to form a surface coating on the workpiece that reduces heat loss from the workpiece. The present disclosure also is directed to an alloy workpieces processed according to methods described herein, and to articles of manufacture including or made from alloy workpieces made according to the methods.

摘要翻译： 合金锭或其他合金工件加工以减少热裂纹的方法通常可以包括将玻璃材料沉积在工件的表面的至少一部分上，并且加热玻璃材料以在工件上形成减少热量的表面涂层 工件损失 本公开还涉及根据本文所述的方法加工的合金工件，以及包括根据该方法制造的合金工件制成的制品。

公开(公告)号：US20140053073A1

公开(公告)日：2014-02-20

申请号：US13592067

申请日：2012-08-22

申请人： Shang Q. Guo ,  Ramesh S. Palakodeti ,  Rajeev Puri ,  Daniela Rosu ,  Cashchakanithara Venugopal ,  Frederick Y. Wu ,  Sai Zeng

发明人： Shang Q. Guo ,  Ramesh S. Palakodeti ,  Rajeev Puri ,  Daniela Rosu ,  Cashchakanithara Venugopal ,  Frederick Y. Wu ,  Sai Zeng

IPC分类号： G06F15/177

CPC分类号： G06F9/468 ,  G06F9/4843 ,  H04L41/22 ,  H04L41/28

摘要： Distributed execution of commands and scripts may comprise a script execution manager having access to a library of executable objects comprising at least one or more of commands or scripts or combination of commands and scripts. A script execution console may be operable to present a graphical user interface for selecting an executable object from the library to execute and for selecting one or more managed computers, on which to execute the selected executable object. The script execution console may be further operable to present a dynamically updated collation of results from execution of the selected executable object. One or more script execution agents may be operable to run on the selected respective one or more managed computers and further operable to communicate with the script execution manager.

公开(公告)号：US08541002B2

公开(公告)日：2013-09-24

申请号：US10571716

申请日：2004-09-13

申请人： Alemseged Truneh ,  Daniel L. Levey ,  Xiaoyan Mo ,  Kenneth P. Leclair ,  Ramesh S. Kashi ,  Chuanliang Liu

发明人： Alemseged Truneh ,  Daniel L. Levey ,  Xiaoyan Mo ,  Kenneth P. Leclair ,  Ramesh S. Kashi ,  Chuanliang Liu

IPC分类号： A61K39/385 ,  A61K38/02 ,  A61K39/245

CPC分类号： A61K39/245 ,  A61K36/185 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/555 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/55583 ,  C07K14/005 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16671

摘要： The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided.

摘要翻译： 本发明涉及用于预防和治疗疱疹病毒感染的方法和组合物。 本发明提供抗原肽，以及药物组合物，其包含能够激活针对疱疹病毒的免疫应答的抗原肽和佐剂的复合物。 本发明还提供了制备抗原肽和抗原肽和佐剂的复合物的方法。 还提供了药物组合物的使用方法。

公开(公告)号：US08381563B2

公开(公告)日：2013-02-26

申请号：US12480246

申请日：2009-06-08

申请人： Urban J. De Souza ,  Robin M. Forbes-Jones ,  Billy B. Hendrick ,  Alonzo L. Liles ,  Ramesh S. Minisandram ,  Sterry A. Shaffer

发明人： Urban J. De Souza ,  Robin M. Forbes-Jones ,  Billy B. Hendrick ,  Alonzo L. Liles ,  Ramesh S. Minisandram ,  Sterry A. Shaffer

IPC分类号： B21D37/16

CPC分类号： B21J1/06 ,  B21K29/00

摘要： A forging die heating or preheating apparatus comprises a burner head comprising a plurality of flame ports. The burner head is oriented to compliment an orientation of at least a region of a forging surface of a forging die and is configured to receive and combust a supply of an oxidizing gas and a supply of a fuel and produce flames at the flame ports. The plurality of flame ports are configured to impinge the flames onto the forging surface of the forging die to substantially uniformly heat at least the region of the forging surface of the forging die.

摘要翻译： 锻造模具加热或预热装置包括具有多个火焰口的燃烧头。 燃烧器头被定向为补充锻造模具的锻造表面的至少一个区域的取向，并且构造成接收和燃烧氧化气体的供应和燃料的供应并在火焰口处产生火焰。 多个火焰口被构造成将火焰撞击到锻造模具的锻造表面上，以基本均匀地加热至少锻造模具的锻造表面的区域。

公开(公告)号：US20110229490A1

公开(公告)日：2011-09-22

申请号：US13061076

申请日：2009-08-25

申请人： Xuhong Li ,  Ramesh S. Kashi ,  Aniket Badkar

发明人： Xuhong Li ,  Ramesh S. Kashi ,  Aniket Badkar

IPC分类号： A61K39/395 ,  A61P29/00 ,  A61P37/06 ,  A61P35/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P19/02 ,  A61P17/06 ,  A61P1/00 ,  A61P3/10

CPC分类号： A61K9/19 ,  A61K39/39591 ,  A61K47/12 ,  A61K47/26 ,  C07K16/244 ,  C07K2317/24

摘要： The present invention provides lyophilized formulations of antibodies, such as antibodies that specifically bind to human interleukin-23 p19 (IL-23p19), or antigen binding fragments thereof.

摘要翻译： 本发明提供抗体的冻干制剂，例如特异性结合人白细胞介素-23p19（IL-23p19）的抗体或其抗原结合片段。

公开(公告)号：US20110059041A1

公开(公告)日：2011-03-10

申请号：US10571716

申请日：2004-09-13

申请人： Alemseged Truneh ,  Daniel L. Levey ,  Xiaoyan Mo ,  Kenneth P. LeClair ,  Ramesh S. Kashi ,  Liu Chuanliang

发明人： Alemseged Truneh ,  Daniel L. Levey ,  Xiaoyan Mo ,  Kenneth P. LeClair ,  Ramesh S. Kashi ,  Liu Chuanliang

IPC分类号： A61K38/20 ,  A61K39/12 ,  A61K39/395 ,  A61K38/21 ,  A61P37/04 ,  A61P31/22

CPC分类号： A61K39/245 ,  A61K36/185 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/555 ,  A61K2039/55566 ,  A61K2039/55577 ,  A61K2039/55583 ,  C07K14/005 ,  C12N2710/16622 ,  C12N2710/16634 ,  C12N2710/16671

摘要： The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions comprising complexes of antigenic peptides and adjuvants that can activate an immune response against herpes viruses. The invention also provides methods of making the antigenic peptides and complexes of antigenic peptides and adjuvants. Methods of use of the pharmaceutical compositions are also provided.

摘要翻译： 本发明涉及用于预防和治疗疱疹病毒感染的方法和组合物。 本发明提供抗原肽，以及药物组合物，其包含能够激活针对疱疹病毒的免疫应答的抗原肽和佐剂的复合物。 本发明还提供了制备抗原肽和抗原肽和佐剂的复合物的方法。 还提供了药物组合物的使用方法。

公开(公告)号：US20100307216A1

公开(公告)日：2010-12-09

申请号：US12480246

申请日：2009-06-08

申请人： Urban J. De Souza ,  Robin M. Forbes-Jones ,  Billy B. Hendrick ,  Alonzo L. Liles ,  Ramesh S. Minsandram ,  Sterry A. Shaffer

发明人： Urban J. De Souza ,  Robin M. Forbes-Jones ,  Billy B. Hendrick ,  Alonzo L. Liles ,  Ramesh S. Minsandram ,  Sterry A. Shaffer

IPC分类号： B21D37/16 ,  B21D37/00

CPC分类号： B21J1/06 ,  B21K29/00

摘要： A forging die heating or preheating apparatus comprises a burner head comprising a plurality of flame ports. The burner head is oriented to compliment an orientation of at least a region of a forging surface of a forging die and is configured to receive and combust a supply of an oxidizing gas and a supply of a fuel and produce flames at the flame ports. The plurality of flame ports are configured to impinge the flames onto the forging surface of the forging die to substantially uniformly heat at least the region of the forging surface of the forging die.

摘要翻译： 锻造模具加热或预热装置包括具有多个火焰口的燃烧头。 燃烧器头被定向为补充锻造模具的锻造表面的至少一个区域的取向，并且构造成接收和燃烧氧化气体的供应和燃料的供应并在火焰口处产生火焰。 多个火焰口被构造成将火焰撞击到锻造模具的锻造表面上，以基本均匀地加热至少锻造模具的锻造表面的区域。

公开(公告)号：US07596773B2

公开(公告)日：2009-09-29

申请号：US11307992

申请日：2006-03-02

申请人： Thenappan Meyyappan ,  Senthil Arasu Thirunavukarasu ,  Sreekantha Madhava katla ,  Ramesh S Guzar

发明人： Thenappan Meyyappan ,  Senthil Arasu Thirunavukarasu ,  Sreekantha Madhava katla ,  Ramesh S Guzar

IPC分类号： G06F17/50 ,  G06F9/45

CPC分类号： G06F17/5072

摘要： Automating optimal placement of macro-blocks in the design of an integrated circuit. A first set of placements is generated and corresponding measures of optimalness for each placement is computed. A new set of placements is generated, with each placement being generated from multiple (“chosen placements”) of the first set of placements. The position of each macro in the new placement is made to be at least substantially identical to the position of the corresponding macro in one of the chosen placements. The placements having high values of optimalness are selected to be the chosen placements, thereby causing the properties of desirable placements to be propagated to new set of placements, as is common in genetic evolution. Another aspect of the present invention enables automatic removal of overlaps in a placement.

摘要翻译： 在集成电路设计中自动优化宏块的布局。 生成第一组展示位置，并计算每个展示位置的最优性度量。 生成一组新的展示位置，每个展示位置都由第一组展示位置的多个（“选择的展示位置”）生成。 将新展示位置中的每个宏的位置与所选择的展示位置之一中的相应宏的位置至少基本相同。 选择具有较高优化值的位置被选择为所选择的位置，从而导致所需位置的属性被传播到新的位置集合，如在遗传进化中常见的。 本发明的另一方面能够自动移除位置中的重叠。

公开(公告)号：US20090124955A1

公开(公告)日：2009-05-14

申请号：US12277139

申请日：2008-11-24

申请人： Ramesh S. Ayyala

发明人： Ramesh S. Ayyala

IPC分类号： A61F9/00 ,  A61M1/00 ,  A61F2/14

CPC分类号： A61F9/0017

摘要： An ophthalmological device comprises an implant member carrying an antifibrotic agent that is released slowly over a prolonged period when inserted into a wound in an eye produced by surgery. The member is placed in the vicinity of a wound created during the surgery to inhibit inflammatory cell proliferation, thereby preventing the growth of fibrous tissue after the eye surgery.

摘要翻译： 眼科装置包括植入物构件，其携带抗纤维化剂，当插入通过手术产生的眼睛中的伤口中时，其被延长释放缓慢释放。 将该构件放置在手术期间产生的伤口附近以抑制炎性细胞增殖，从而防止眼外科手术后纤维组织的生长。

公开(公告)号：US20080002590A1

公开(公告)日：2008-01-03

申请号：US11427955

申请日：2006-06-30

申请人： Tessil Thomas ,  Henk Neefs ,  Ramesh S.

发明人： Tessil Thomas ,  Henk Neefs ,  Ramesh S.

IPC分类号： H04J3/14

CPC分类号： G06F13/1668 ,  G06F11/073 ,  G06F11/076 ,  G06F11/0781 ,  G06F11/0793

摘要： A memory agent that communicates with another memory agent over links may include error hardware to monitor errors in the links. In some embodiments, the error hardware may include logic to classify the errors into different severity levels, control corrective action based on the severity level of errors, and/or perform various levels of reset based on the severity level of errors. Other embodiments are disclosed and claimed.

摘要翻译： 通过链路与另一存储器代理进行通信的存储器代理可以包括用于监视链路中的错误的错误硬件。 在一些实施例中，错误硬件可以包括将错误分类到不同严重性级别的逻辑，基于错误的严重性级别来控制纠正措施，和/或基于错误的严重性水平执行各种复位级别。 公开和要求保护其他实施例。