公开(公告)号：US20060142300A1

公开(公告)日：2006-06-29

申请号：US10510892

申请日：2003-04-07

Applicant: Manne Reddy ,  Chakilam Raju ,  Vetukuri Venkata Naga Kali Raju ,  Ningam Reddy ,  Rapolu Kumar

Inventor： Manne Reddy ,  Chakilam Raju ,  Vetukuri Venkata Naga Kali Raju ,  Ningam Reddy ,  Rapolu Kumar

IPC: A61K31/496 ,  C07D403/02

CPC classification number: C07D215/56

Abstract: The present invention relates to the novel anhydrous crystalline forms I and II of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (gatifloxacin) which can be depicted as Formula (I). The present invention also relates to methods of making the anhydrous Forms I and II of Gatifloxacin, use of the forms and methods for preparing them.

Abstract translation: 本发明涉及1-环丙基-6-氟-8-甲氧基-7-（3-甲基-1-哌嗪基）-4-氧代-1,4-二氢喹啉-3-羧酸的新的无水结晶形式I和II 可以描述为式（I）的酸（加替沙星）。 本发明还涉及制备加替沙星的无水形式I和II的方法，使用形式和方法来制备它们。

公开(公告)号：US20050137227A1

公开(公告)日：2005-06-23

申请号：US10822154

申请日：2004-04-09

Applicant: Manne Reddy ,  Sajja Eswaraiah ,  Vetukuri Venkata Naga Raju ,  Rapolu Kumar ,  Ningam Srinivasreddy ,  Vedantham Ravindra

Inventor： Manne Reddy ,  Sajja Eswaraiah ,  Vetukuri Venkata Naga Raju ,  Rapolu Kumar ,  Ningam Srinivasreddy ,  Vedantham Ravindra

IPC: A61K31/4709 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4709

Abstract: A new crystalline Form III of moxifloxacin monohydrochloride and processes for making the crystalline form as well as compositions, pharmaceutical compositions, and methods utilizing the crystalline form are described.

Abstract translation: 描述莫西沙星单盐酸盐的新结晶形式III和用于制备结晶形式的方法以及使用结晶形式的组合物，药物组合物和方法。