公开(公告)号：US06271394B1

公开(公告)日：2001-08-07

申请号：US09704500

申请日：2000-11-02

申请人： Ratna Shekhar ,  Michael John Girgis

发明人： Ratna Shekhar ,  Michael John Girgis

IPC分类号： C07D20700

CPC分类号： C07D207/16 ,  C07B2200/11 ,  C07C231/02 ,  C07C237/02

摘要： Disclosed are methods for the synthesis of amino acid amides which comprise providing a fixed bed of a cation exchange resin, admixing a primary alcohol and an amino acid in a reaction vessel in fluid communication with the fixed bed to form a first mixture, contacting the fixed bed of cation exchange resin with the first mixture for a period of time, thereby causing amino acid ester intermediate to be formed on the cation exchange resin, adding liquid ammonia to the reaction vessel, and contacting the fixed bed of cation exchange resin with ammonia, the fixed bed having previously been contacted with the first mixture.

摘要翻译： 公开了用于合成氨基酰胺的方法，其包括提供阳离子交换树脂的固定床，在与固定床流体连通的反应容器中混合伯醇和氨基酸以形成第一混合物，使固定的 将阳离子交换树脂与第一混合物一段时间，由此在阳离子交换树脂上形成氨基酸酯中间体，向反应容器中加入液氨，并将阳离子交换树脂的固定床与氨接触， 固定床先前已经与第一混合物接触。

公开(公告)号：US06740776B2

公开(公告)日：2004-05-25

申请号：US10196600

申请日：2002-07-15

申请人： Ratna Shekhar ,  Michael John Girgis

发明人： Ratna Shekhar ,  Michael John Girgis

IPC分类号： C07C5123

CPC分类号： C07C51/235 ,  C07C63/04

摘要： A low temperature process for preparing an aromatic acid having formula (I), said process comprising reacting an aromatic aldehyde having formula (II) with a gas having an oxygen content of 1 to 100 weight percent, based on the total weight of the gas, at a temperature of about 20° C. to less than 100° C. in the presence of a supported Group VIII metal catalyst, and a solvent having a flash point greater than 95° C. and/or a melting point less than 55° C., provided that the flash point of the solvent is greater than the reaction temperature, wherein R1 and R2 are independently selected from the group consisting of hydrogen and a C1-C8 linear, branched or cyclic alkyl group. The process of the invention yields an aromatic acid in excellent yield, and (i) does not involve the use of deleterious oxidizing agents; (ii) is essentially free of by-products; and (iii) is accomplished at a temperature of less than 100° C.

摘要翻译： 用于制备具有式（I）的芳族酸的低温方法，所述方法包括使具有式（II）的芳族醛与基于气体总重量的1至100重量％的氧含量的气体反应， 在负载的第VIII族金属催化剂的存在下，在约20℃至小于100℃的温度下，和闪点大于95℃和/或熔点小于55℃的溶剂 条件是溶剂的闪点大于反应温度，其中R 1和R 2独立地选自氢和C 1 -C 8直链，支链或环状的烷基。 本发明的方法得到优异的收率的芳香酸，（i）不涉及有害氧化剂的使用; （ii）基本上不含副产物; 和（iii）在小于100℃的温度下完成。