公开(公告)号：US08983601B2

公开(公告)日：2015-03-17

申请号：US13405909

申请日：2012-02-27

申请人： Kiyotaka Fukamachi ,  Alex Massiello ,  Mariko Kobayashi ,  Ray Dessoffy ,  Eugene Jung ,  Shubhayu Basu

发明人： Kiyotaka Fukamachi ,  Alex Massiello ,  Mariko Kobayashi ,  Ray Dessoffy ,  Eugene Jung ,  Shubhayu Basu

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36139 ,  A61N1/3627

摘要： Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control. Physiologic inputs from a neuromodulation system's own sensors or from separate implanted or external cardiovascular hemodynamic sensor systems can be used for closed loop control over the balance of sympathetic and parasympathetic cardiac autonomic effects on the patient's cardiac function in real time response to chronic and transient physiologic needs.

摘要翻译： 通过电动调节在心脏心包空间内的血管外位置支配患者心脏的交感神经和副交感神经自主神经纤维来治疗患者的心力衰竭。 血管外部位是胸腔内任何合适的单一位置，其携带交感神经和副交感神经，如心脏神经丛或心包横向窦或任何两个分离的血管外部位，一个位点主要携带交感神经，另一个位点主要携带 副交感神经，用于电调节自主神经控制的平衡。 来自神经调节系统的自身传感器或来自分离的植入或外部心血管血液动力学传感器系统的生理输入可用于闭环控制对交感神经和副交感神经心脏自主影响对患者心脏功能的平衡，实时响应慢性和短暂的生理需求 。

公开(公告)号：US20120221072A1

公开(公告)日：2012-08-30

申请号：US13405909

申请日：2012-02-27

申请人： Kiyotaka FUKAMACHI ,  Alex MASSIELLO ,  Mariko KOBAYASHI ,  Ray DESSOFFY ,  Eugene JUNG ,  Shubhayu BASU

发明人： Kiyotaka FUKAMACHI ,  Alex MASSIELLO ,  Mariko KOBAYASHI ,  Ray DESSOFFY ,  Eugene JUNG ,  Shubhayu BASU

IPC分类号： A61N1/365 ,  A61N1/362

CPC分类号： A61N1/36114 ,  A61N1/36139 ,  A61N1/3627

摘要： Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control. Physiologic inputs from a neuromodulation system's own sensors or from separate implanted or external cardiovascular hemodynamic sensor systems can be used for closed loop control over the balance of sympathetic and parasympathetic cardiac autonomic effects on the patient's cardiac function in real time response to chronic and transient physiologic needs.

摘要翻译： 通过电动调节在心脏心包空间内的血管外位置支配患者心脏的交感神经和副交感神经自主神经纤维来治疗患者的心力衰竭。 血管外部位是胸腔内任何合适的单一位置，其携带交感神经和副交感神经，如心脏神经丛或心包横向窦或任何两个分离的血管外部位，一个位点主要携带交感神经，另一个位点主要携带 副交感神经，用于电调节自主神经控制的平衡。 来自神经调节系统的自身传感器或来自分离的植入或外部心血管血液动力学传感器系统的生理输入可用于闭环控制对交感神经和副交感神经心脏自主影响对患者心脏功能的平衡，实时响应慢性和短暂的生理需求 。