公开(公告)号：US20130184167A1

公开(公告)日：2013-07-18

申请号：US12809726

申请日：2008-12-18

申请人： Pablo Villoslada Díaz ,  Ricardo Palacios Urtasun ,  Jorge Sepulcre Bernad ,  Laureano Simón Buela ,  Antonio Martínez Martínez

发明人： Pablo Villoslada Díaz ,  Ricardo Palacios Urtasun ,  Jorge Sepulcre Bernad ,  Laureano Simón Buela ,  Antonio Martínez Martínez

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G16H50/70 ,  Y02A90/26

摘要： The present invention relates to a series of genes the expression of which is altered in subjects suffering multiple sclerosis with respect to healthy subjects or in subjects suffering multiple sclerosis with a good prognosis with respect to subjects suffering multiple sclerosis with a bad prognosis. A subset formed by 13 genes and two clinical variables which allows predicting the progress of a patient with a high reliability has been validated from an initial set of genes which showed said differential expression. From said expression values, the invention provides methods for predicting the progress of a patient diagnosed with multiple sclerosis from tables of conditional probability between the expression levels of a determined gene or group of genes and the probability that the patient has a good or bad prognosis of the disease.

摘要翻译： 本发明涉及一系列基因，其表达在相对于健康受试者的多发性硬化患者或患有多发性硬化的受试者中相对于具有不良预后的多发性硬化患者具有良好预后而改变。 由显示所述差异表达的初始基因组验证了由13个基因和两个临床变量形成的子集，其允许预测具有高可靠性的患者进展。 根据所述表达值，本发明提供了从确定的基因或基因组表达水平之间的条件概率表中预测诊断为多发性硬化症的患者的进展的方法以及患者具有良好或不良预后的可能性 这种病。