公开(公告)号：US07572625B2

公开(公告)日：2009-08-11

申请号：US11435690

申请日：2006-05-18

申请人： Liza J. Davis ,  Kim Robertson ,  Richard C. Tooley, Jr.

发明人： Liza J. Davis ,  Kim Robertson ,  Richard C. Tooley, Jr.

IPC分类号： C12M3/00

CPC分类号： A61L31/16 ,  A61L27/227 ,  A61L27/34 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L2300/602

摘要： A medical device coated with carrier macromolecules, wherein the carrier macromolecules are conjugated with a therapeutic agent. The carrier macromolecules may be antibodies which bind the therapeutic agent at the antigen binding site or by covalent bonding. The carrier macromolecules may be tethered to the surface of or dispersed within a coating on the medical device. The carrier macromolecules may release the therapeutic agent upon exposure to a trigger, which may be exposure to an aqueous environment, or a change in the pH or the ionic strength of the environment. The carrier macromolecules may also be bispecific antibodies directed to both a therapeutic agent and a target antigen. In some cases, binding of the target antigen causes the therapeutic agent to be released from the bispecific antibody. Also provided are methods of controlling the release and targeting of therapeutic agents eluted from a medical device.

摘要翻译： 涂覆有载体大分子的医疗装置，其中载体大分子与治疗剂缀合。 载体大分子可以是在抗原结合位点或通过共价键结合治疗剂的抗体。 载体大分子可以连接到医疗装置上的涂层的表面或分散在其中。 载体大分子可能暴露于可能暴露于水性环境的触发剂或pH或环境离子强度的变化下释放治疗剂。 载体大分子也可以是针对治疗剂和靶抗原的双特异性抗体。 在一些情况下，靶抗原的结合导致治疗剂从双特异性抗体释放。 还提供了控制从医疗装置洗脱的治疗剂的释放和靶向的方法。