公开(公告)号：US09656228B2

公开(公告)日：2017-05-23

申请号：US12999578

申请日：2009-06-16

申请人： Daniel Palmer ,  Richard Calder ,  Owen Shadick

发明人： Daniel Palmer ,  Richard Calder ,  Owen Shadick

IPC分类号： A61K9/50 ,  B01J2/08 ,  A61K9/16

CPC分类号： B01J2/08 ,  A61K9/1647 ,  A61K9/1694

摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

公开(公告)号：US20110160134A1

公开(公告)日：2011-06-30

申请号：US12999578

申请日：2009-06-16

申请人： Daniel Palmer ,  Richard Calder ,  Owen Shadick

发明人： Daniel Palmer ,  Richard Calder ,  Owen Shadick

IPC分类号： A61K38/22 ,  C08G63/08 ,  B01L3/00 ,  A61P5/00

CPC分类号： B01J2/08 ,  A61K9/1647 ,  A61K9/1694

摘要： A method of making solid beads is disclosed, said method comprising: (i) providing a microfluidic device comprising a carrier fluid conduit and a functional fluid conduit which meet at a junction region; (ii) providing a laminar flow of a functional fluid comprising a solvent and a solute along the functional fluid conduit and providing a laminar flow of a carrier fluid along the carrier fluid conduit so as to form droplets of functional fluid in a flow of carrier fluid; (iii) cooling the segments of functional fluid in a conduit of the microfluidic device to form cooled (preferably frozen) droplets; and (iv) providing a liquid into intimate admixture with the cooled droplets so as to cause said solvent to exit said cooled droplets, thus forming solid beads. A microfluidic device for use in such a method is also disclosed.

摘要翻译： 公开了一种制备固体珠粒的方法，所述方法包括：（i）提供微流体装置，其包括在连接区域相遇的载体流体导管和功能流体导管; （ii）提供功能流体的层流，其包括沿着功能流体导管的溶剂和溶质，并且沿载体流体导管提供载体流体的层流，以便在载体流体流中形成功能流体液滴 ; （iii）冷却所述微流体装置的管道中的功能流体段以形成冷却（优选冷冻的）液滴; 和（iv）将液体与冷却的液滴紧密混合，以使所述溶剂离开所述冷却的液滴，从而形成固体珠粒。 还公开了一种用于这种方法的微流体装置。