公开(公告)号：US06183420B2

公开(公告)日：2001-02-06

申请号：US08985799

申请日：1997-12-05

申请人： Nareak Douk ,  Richard A. Gambale ,  Richard Choh

发明人： Nareak Douk ,  Richard A. Gambale ,  Richard Choh

IPC分类号： A61B814

CPC分类号： A61M25/09 ,  A61M2025/0915 ,  A61M2025/09175

摘要： An angioplasty guidewire includes a proximal shaft formed with an axial passage and a variable stiffness intermediate section extending axially from the tubular shaft and having a corridor aligned axially with the passage and terminating at a distal joint. The intermediate section comprises a plurality of stiffening elements. A core element is slidably disposed axially through the passage and includes a distal end projecting into the corridor and attached to the distal joint while a flexible distal tip is mounted to the end of the intermediate portion and projects axially therefrom.

摘要翻译： 血管成形术导丝包括近端轴，其形成有轴向通道和从管状轴向轴向延伸的可变刚度中间部分，并且具有与通道轴向对齐并终止于远端关节的走廊。 中间部分包括多个加强元件。 芯元件可滑动地布置在通过该通道的轴向上，并且包括突出到走廊中并连接到远端接头的远端，同时柔性远侧末端安装到中间部分的端部并且从其轴向突出。

公开(公告)号：US6113557A

公开(公告)日：2000-09-05

申请号：US879569

申请日：1997-06-20

申请人： John R. Fagan ,  Richard Choh ,  Richard Morrill

发明人： John R. Fagan ,  Richard Choh ,  Richard Morrill

IPC分类号： A61B5/00 ,  A61B8/14 ,  A61M25/09

CPC分类号： A61M25/09 ,  A61M2025/09083 ,  A61M2025/0915 ,  A61M2025/09175

摘要： An angioplasty guidewire includes a proximal shaft and an intermediate section extending from the shaft to a distal joint and having a stiffener and a flexible member. The stiffener and the flexible member are disposed in coaxial slidable relationship and operable, as the stiffener and flexible member undergo relative axial shifting, to cooperatively impart a variable stiffening force on the intermediate section. A flexible distal tip mounts to the end of the intermediate section and projects axially therefrom.

摘要翻译： 血管成形术导丝包括近轴和从轴延伸到远侧关节并具有加强件和柔性构件的中间部分。 加强件和柔性构件以同轴可滑动的关系设置，并且当加强件和柔性构件进行相对轴向移动时可操作，以协同地在中间部分上赋予可变的加强力。 柔性远端尖端安装到中间部分的端部并从其轴向突出。

公开(公告)号：US20050004558A1

公开(公告)日：2005-01-06

申请号：US10899368

申请日：2004-07-26

申请人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Richard Choh ,  Sean Forde

发明人： Richard Gambale ,  Stephen Forcucci ,  Michael Weiser ,  Richard Choh ,  Sean Forde

IPC分类号： A61B17/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/94 ,  A61K9/22 ,  A61L27/00 ,  A61M37/00

CPC分类号： A61F2/94 ,  A61F2/2493 ,  A61F2230/0091 ,  A61F2250/0067

摘要： Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly well suited for implantation into the myocardium of the heart. The implants are configured to be flexible so that they compress and expand with corresponding movement of the surrounding tissue into which they are implanted. The flow of blood into the implant and pooling of the blood in and around the implant leads to thrombosis and fibrin growth, a healing process that leads to angiogenesis in the tissue surrounding the implant. Additionally, the implants may contain an angiogenic substance or a thrombus of blood, preloaded or injected after implantation to aid in initiating angiogenesis.

摘要翻译： 提供了用于促进缺血组织中血管生成的植入物和相关递送系统。 植入物可以经皮，胸部或手术递送，并且特别适合于植入心脏的心肌。 植入物被构造成具有柔性的，使得它们随着植入其中的周围组织的相应运动而压缩和扩张。 血液进入植入物的流动以及血液在植入物中和周围的汇集导致血栓形成和纤维蛋白生长，这是导致植入物周围组织血管生成的愈合过程。 此外，植入物可能含有血管生成物质或血栓，预先加载或在植入后注射以帮助起始血管发生。