Inhibition of beta cell degeneration
    4.
    发明授权
    Inhibition of beta cell degeneration 有权
    抑制β细胞变性

    公开(公告)号:US07064145B2

    公开(公告)日:2006-06-20

    申请号:US09790002

    申请日:2001-02-21

    IPC分类号: A61K31/401

    摘要: Methods for preventing beta cell degeneration, such as necrosis or apoptosis of beta cells in a subject, comprising administering a DPP-IV inhibitor to a subject in need thereof. The invention furthermore relates to a method for increasing the number and/or the size of beta cells. The invention also relates to a method for delaying the progression of Impaired Glucose Tolerance (IGT) to type 2 diabetes, as well as a method for delaying the progression of non-insulin demanding type 2 diabetes to insulin-demanding type 2 diabetes.

    摘要翻译: 用于预防β细胞变性的方法,例如受试者中β细胞的坏死或凋亡,包括向有需要的受试者施用DPP-IV抑制剂。 本发明还涉及增加β细胞的数量和/或尺寸的方法。 本发明还涉及将葡萄糖耐量受损(IGT)延缓到2型糖尿病的进展的方法,以及用于将非胰岛素要求2型糖尿病进展为胰岛素要求2型糖尿病的方法。