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公开(公告)号:US20110229572A1
公开(公告)日:2011-09-22
申请号:US12672031
申请日:2008-08-18
申请人: Andrew Lennard Lewis , Richard Edward John Forster , Mroa Voctoria Gonzalez-Fajardo , Yiqing Tang , Andrew Willam LLoyd , Gary John Phillips
发明人: Andrew Lennard Lewis , Richard Edward John Forster , Mroa Voctoria Gonzalez-Fajardo , Yiqing Tang , Andrew Willam LLoyd , Gary John Phillips
IPC分类号: A61K9/00 , A61K31/704 , A61K31/4745 , A61K31/436 , A61K31/192 , A61P35/00 , A61K9/14
摘要: A composition comprising microspheres of a polymer matrix, having two different pharmaceutical actives having complementary, usually synergistic, activity in killing cells. The compositions have particular utility for treating tumours. Useful combinations are doxorubicin with rapamycin, irinotecan with ibuprofen, ibuprofen with doxorubicin and irinotecan with doxorubicin. The polymer matrix is preferably a crosslinked polyvinyl alcohol. The drugs may be included in the same microsphere, or microspheres each with an individual pharmaceutical agent may be mixed together. The microspheres are preferably used in chemoembolisation of tumours.
摘要翻译: 包含聚合物基质微球的组合物,具有两种不同的药物活性物质,其在杀伤细胞中具有互补的,通常协同的活性。 该组合物具有治疗肿瘤的特殊用途。 有用的组合是多柔比星与雷帕霉素,伊立替康与布洛芬,布洛芬与多柔比星和伊立替康与多柔比星。 聚合物基质优选为交联聚乙烯醇。 药物可以包含在相同的微球中,或者每个具有单个药剂的微球可以混合在一起。 微球优选用于肿瘤的化学栓塞。
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公开(公告)号:US20110293672A1
公开(公告)日:2011-12-01
申请号:US13132259
申请日:2009-11-25
IPC分类号: A61K9/14 , A61K31/136 , A61P35/00 , A61K31/436 , C07D491/22 , A61P1/18 , A61K31/704 , A61K31/4745
CPC分类号: A61K9/0019 , A61K9/1635 , A61K9/1652 , A61K31/00 , A61K31/337 , A61K31/436 , A61K31/4745 , A61K31/704
摘要: There is provided a composition comprising microspheres which comprise a water-insoluble, water-swellable polymer and associated with the polymer, in releasable form, a chemotherapeutic agent, for use in the treatment of a pancreatic tumour or cyst, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water, wherein the polymer is anionically charged at pH7 and the chemotherapeutic agent is cationically charged and electrostatically associated with the polymer. Also provided are methods of treating pancreatic tumours or cysts using this composition.
摘要翻译: 提供包含微球的组合物,其包含水不溶性的水溶胀性聚合物,并且与可释放形式的聚合物缔合,用于治疗胰腺肿瘤或囊肿的化学治疗剂,其中当平衡时所述微球体 在37℃的水中,包含基于聚合物加水重量的至少40wt%的水,其中聚合物在pH7下被阴离子充电,并且化学治疗剂被阳离子充电并与聚合物静电相关。 还提供了使用该组合物治疗胰腺肿瘤或囊肿的方法。
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