公开(公告)号：US20070122441A1

公开(公告)日：2007-05-31

申请号：US11601949

申请日：2006-11-20

申请人： Hironobu Murata ,  Richard Koespel ,  Sang Lee ,  Alan Russell

发明人： Hironobu Murata ,  Richard Koespel ,  Sang Lee ,  Alan Russell

IPC分类号： A01N57/00 ,  A01N25/00

CPC分类号： A01N25/34 ,  A01N33/12 ,  A01N37/36 ,  A01N43/40 ,  A01N55/00

摘要： A biocidal article, includes a surface including a plurality of polymers covalently attached to the surface. The polymers include biocidal cationic groups. The polymers have a molecular weight distribution or polydispersity less than 3. A grafting density of the polymers on the surface is controlled, average degree of polymerization of the polymers is controlled and repeat units of the polymers are chosen to provide a predetermined charge density arising from the cationic groups. A method of analyzing biocidal activity of biocidal surface agents includes the steps: attaching a plurality of chemical entities to one or more surfaces so that at least one physiochemical property is varied, each of the chemical entities comprising at least one biocidally active component; and exposing the chemical entities to at least one biological agent to determine the effect of the at least one physiochemical property upon biocidal activity. The biocidal activity can, for example, be antibacterial activity or sporicidal activity. The at least one physiochemical property can, for example, be varied in a preferably systematic manner.

摘要翻译： 杀生物制品包括包含共价连接在表面上的多个聚合物的表面。 聚合物包括杀生物阳离子基团。 聚合物具有小于3的分子量分布或多分散性。控制聚合物在表面上的接枝密度，控制聚合物的平均聚合度，并且选择聚合物的重复单元以提供由 阳离子基团。 分析杀生物表面活性剂的杀生物活性的方法包括以下步骤：将多个化学实体连接到一个或多个表面，使得至少一个理化特性变化，每个化学实体包含至少一种生物活性成分; 以及将所述化学实体暴露于至少一种生物试剂以确定所述至少一种理化化学性质对杀生物活性的影响。 杀生物活性可以例如是抗菌活性或杀孢子活性。 至少一种理化特性可以例如以优选系统的方式变化。