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公开(公告)号:US20080153854A1
公开(公告)日:2008-06-26
申请号:US12032438
申请日:2008-02-15
申请人: Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard William Luke , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
发明人: Brian Aquila , Michael Howard Block , Audrey Davies , Jayachandran Ezhuthachan , Sandra Filla , Richard William Luke , Timothy Pontz , Daniel John Russell , Maria-Elena Theoclitou , XiaoLan Zheng
IPC分类号: A61K31/519 , C07D487/04 , A61P35/00
CPC分类号: C07D513/04
摘要: This invention relates to novel compounds having the formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the specification and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
摘要翻译: 本发明涉及具有式(I)的新化合物,其中R 1,R 2,R 3,R 4, R 5,R 5,R 6,R 7,R 8和R 9, SUP>如说明书及其药物组合物及其使用方法中所定义。 这些新化合物提供癌症的治疗或预防。
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2.
公开(公告)号:US20050256140A1
公开(公告)日:2005-11-17
申请号:US10523401
申请日:2003-08-01
IPC分类号: A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P9/10 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D473/34 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D491/02 , C07D498/02
CPC分类号: C07D487/04 , C07D473/34 , C07D491/04 , C07D495/04 , C07D513/04
摘要: A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I): G is selected from O, S and NR5; Z is selected from N and CR6; Q1 is selected from optionally substituted aryl and heteroaryl, and the substituents R1 to R6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.
摘要翻译: 式(I)的化合物,其中A与连接的碳原子一起形成稠合的5元杂芳基环,其中所述杂芳基环含有1或2个选自O,N和S的杂原子,并且其中 含有G的5元环与在间位A中形成的环连接在通式(I)中标记为#的桥头碳上:G选自O,S和NR 5; Z选自N和CR 6; Q 1选自任选取代的芳基和杂芳基,并且取代基R 1至R 6如文中所定义,用于 在温血动物如人中产生抗血管生成作用。
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