公开(公告)号：US20130281465A1

公开(公告)日：2013-10-24

申请号：US13994043

申请日：2011-12-16

申请人： Dai Nozawa ,  Ryo Suzuki ,  Aya Futamura ,  Rie Shimono ,  Masahito Abe ,  Hiroshi Ohta ,  Yuko Araki

发明人： Dai Nozawa ,  Ryo Suzuki ,  Aya Futamura ,  Rie Shimono ,  Masahito Abe ,  Hiroshi Ohta ,  Yuko Araki

IPC分类号： C07D403/12 ,  C07D405/14 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/4192 ,  C07D401/14

CPC分类号： A61K31/4192 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

摘要： A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which is useful for the treatment or prevention of diseases such sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, pain, gastrointestinal diseases, epilepsy, inflammation, immune-related diseases, endocrine-related diseases, and hypertension, and of which the action relies on an orexin (OX) receptor antagonistic activity.

摘要翻译： 由式（IA）表示的化合物或其药学上可接受的盐，其可用于治疗或预防睡眠障碍，抑郁症，焦虑障碍，恐慌症，精神分裂症，药物依赖，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病 ，饮食失调，疼痛，胃肠道疾病，癫痫，炎症，免疫相关疾病，内分泌相关疾病和高血压，其作用依赖于食欲素（OX）受体拮抗作用。