公开(公告)号：US20090131487A1

公开(公告)日：2009-05-21

申请号：US12338588

申请日：2008-12-18

申请人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

发明人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

IPC分类号： A61K31/4409 ,  A61K31/197 ,  A61P35/00 ,  A61P7/00

CPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/6949

摘要： Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

摘要翻译： 公开了具有连接到非肽有机支架上的多个无环间苯二甲酸基团和其药物组合物的生长因子结合化合物。 还教导了施用和使用生长因子结合化合物或生长因子结合组合物的方法。 这些新的生长因子结合化合物可用于治疗血管发生，过度的细胞增殖，肿瘤生长及其组合以及抑制生长因子结合细胞和磷酸化。

公开(公告)号：US07718700B2

公开(公告)日：2010-05-18

申请号：US12338588

申请日：2008-12-18

申请人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

发明人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

IPC分类号： A61K31/195

CPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/6949

摘要： Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

摘要翻译： 公开了具有连接到非肽有机支架上的多个无环间苯二甲酸基团和其药物组合物的生长因子结合化合物。 还教导了施用和使用生长因子结合化合物或生长因子结合组合物的方法。 这些新的生长因子结合化合物可用于治疗血管发生，过度的细胞增殖，肿瘤生长及其组合以及抑制生长因子结合细胞和磷酸化。

公开(公告)号：US07482483B2

公开(公告)日：2009-01-27

申请号：US11044980

申请日：2005-01-27

申请人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

发明人： Said M. Sebti ,  Andrew D. Hamilton ,  Rishi Jain

IPC分类号： C07C229/00 ,  A61K31/195

CPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/6949

摘要： Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

摘要翻译： 公开了具有连接到非肽有机支架上的多个无环间苯二甲酸基团和其药物组合物的生长因子结合化合物。 还教导了施用和使用生长因子结合化合物或生长因子结合组合物的方法。 这些新的生长因子结合化合物可用于治疗血管发生，过度的细胞增殖，肿瘤生长及其组合以及抑制生长因子结合细胞和磷酸化。

公开(公告)号：US20050197401A1

公开(公告)日：2005-09-08

申请号：US11044980

申请日：2005-01-27

申请人： Said Sebti ,  Andrew Hamilton ,  Rishi Jain

发明人： Said Sebti ,  Andrew Hamilton ,  Rishi Jain

IPC分类号： A61K31/195 ,  A61K47/48 ,  C07C237/42

CPC分类号： B82Y5/00 ,  A61K47/54 ,  A61K47/6949

摘要： Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the growth factor binding compositions are also taught. These novel growth factor binding compounds are useful for treating angiogenesis, excessive cellular proliferation, tumor growth, and a combination thereof as well as inhibiting growth factor binding to cells and phosphorylation.

摘要翻译： 公开了具有连接到非肽有机支架上的多个无环间苯二甲酸基团和其药物组合物的生长因子结合化合物。 还教导了施用和使用生长因子结合化合物或生长因子结合组合物的方法。 这些新的生长因子结合化合物可用于治疗血管发生，过度的细胞增殖，肿瘤生长及其组合以及抑制生长因子结合细胞和磷酸化。