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公开(公告)号：US08158665B2
公开(公告)日：2012-04-17
申请号：US12720023
申请日：2010-03-09
申请人： Richard Caldwell , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
发明人： Richard Caldwell , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： A61K31/42
CPC分类号： C07D413/12 , C07D261/08
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
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公开(公告)号：US20110034507A1
公开(公告)日：2011-02-10
申请号：US12665772
申请日：2008-06-13
IPC分类号： A61K31/4725 , C07D413/12 , C07D417/14 , C07D413/14 , C07D409/12 , C07D417/12 , C07D413/06 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/428 , A61K31/423 , A61P3/00 , A61P1/16 , A61P35/00
CPC分类号： C07D413/12 , C07D261/08 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to farnesoid X receptors (FXR, NR1H4). FXR is a member of the nuclear receptor class of ligand-activate transcription factors. More particularly, the present invention relates to compounds useful as agonists for FXR, pharmaceutical formulations comprising such compounds, and therapeutic use of the same. Novel isoxazole compounds are disclosed as part of pharmaceutical compositions for the treatment of a condition mediated by decreased FXR activity, such as obesity, diabetes, cholestatic liver disease, liver fibrosis, and metabolic syndrome.
摘要翻译： 本发明涉及法呢酯X受体（FXR，NR1H4）。 FXR是配体 - 激活转录因子核受体类的成员。 更具体地说，本发明涉及可用作FXR激动剂的化合物，包含这些化合物的药物制剂及其治疗用途。 公开了新的异恶唑化合物作为用于治疗由FXR活性降低（如肥胖，糖尿病，胆汁淤积性肝病，肝纤维化和代谢综合征）介导的病症的药物组合物的一部分。
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公开(公告)号：US20100160398A1
公开(公告)日：2010-06-24
申请号：US12720023
申请日：2010-03-09
申请人： Richard Caldwell , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
发明人： Richard Caldwell , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
CPC分类号： C07D413/12 , C07D261/08
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译： 本发明提供了新的取代的异恶唑化合物，药物组合物，治疗用途及其制备方法。
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公开(公告)号：US20100120775A1
公开(公告)日：2010-05-13
申请号：US12446594
申请日：2007-10-23
申请人： Jonathan York Bass, III , David Norman Deaton , Justin Caravella , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
发明人： Jonathan York Bass, III , David Norman Deaton , Justin Caravella , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： A61K31/498 , C07D215/20 , A61K31/47 , C07D413/02 , A61K31/517 , C07D241/36 , A61P3/04 , A61P3/10 , A61P1/16
CPC分类号： C07D413/14 , C07D413/12
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
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公开(公告)号：US07960552B2
公开(公告)日：2011-06-14
申请号：US11876906
申请日：2007-10-23
申请人： Jonathan York Bass, III , Justin Caravella , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
发明人： Jonathan York Bass, III , Justin Caravella , David Norman Deaton , Robert Blount McFadyen , Frank Navas, III , Paul Kenneth Spearing
IPC分类号： C07D401/00
CPC分类号： C07D413/14 , C07D413/12
摘要： The present invention provides novel substituted isoxazole compounds, pharmaceutical compositions, therapeutic uses and processes for preparing the same.
摘要翻译： 本发明提供了新的取代的异恶唑化合物，药物组合物，治疗用途及其制备方法。
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