公开(公告)号：US06913825B2

公开(公告)日：2005-07-05

申请号：US10251934

申请日：2002-09-20

申请人： Agnes E. Ostafin ,  Robert Nooney ,  Edward Maginn

发明人： Agnes E. Ostafin ,  Robert Nooney ,  Edward Maginn

IPC分类号： B32B5/16

CPC分类号： C01B37/02 ,  B22F1/0018 ,  B22F1/02 ,  B22F9/24 ,  B22F2001/0037 ,  B22F2998/00 ,  B82Y30/00 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  B22F1/0022

摘要： Nanoparticles, nanocomposites, and methods for making the nanoparticles and nanocomposites are disclosed. Illustrated methods include preparing a nanocomposite particle by binding a silicate compound to the surface of a core particle in an aqueous suspension, adding a silicate source and an organic surfactant template, and stirring the aqueous suspension to obtain silicate growth. The resultant nanoparticles and nanocomposites have desired mesoporous silicate structure

摘要翻译： 公开了纳米颗粒，纳米复合材料和制备纳米颗粒和纳米复合材料的方法。 说明的方法包括通过在硅酸盐源和有机表面活性剂模板中加入硅酸盐化合物与芯颗粒的表面结合制备纳米复合颗粒，并搅拌水悬浮液以获得硅酸盐生长。 所得的纳米颗粒和纳米复合材料具有所需的介孔硅酸盐结构

公开(公告)号：US20100332183A1

公开(公告)日：2010-12-30

申请号：US12863120

申请日：2009-01-19

申请人： Robert Nooney ,  Ondrej Stranik

发明人： Robert Nooney ,  Ondrej Stranik

IPC分类号： G01N21/64 ,  C09K11/06 ,  G01G9/00

CPC分类号： G01N21/6428

摘要： The invention provides dye-doped nanoparticles comprising silica doped with molecules of a near infra red dye comprising 4,5-Benzo-1′-ethyl-3,3,3′,3′-tetramethyl-1-(4-sulfobutyl)indodicarbocyanin-5′-acetic acid N-succinimidyl ester, and dye-doped nanoparticles derivatised with a functional group. The invention further provides a method of manufacture of dye-doped nanoparticles comprising the steps of preparing a dye mixture by dissolving a dye in the surfactant hexanol and conjugating the dye with an organosilane, forming a microemulsion of water droplets in oil, adding the dye mixture to the microemulsion, and adding a source of silicon and a catalyst to the microemulsion, which causes growth of silica nanoparticles in the water droplets of the microemulsion which silica nanoparticles are doped with the dye. The invention further provides, in a dye-doped nanoparticle, a method of determining a % weight of the dye which yields a required relative fluorescent intensity from the nanoparticle.

摘要翻译： 本发明提供染料掺杂的纳米颗粒，其包含掺杂有近红外染料分子的二氧化硅，其包含4,5-苯并-1'-乙基-3,3,3'，3'-四甲基-1-（4-磺丁基）异二碳云母 -5'-乙酸N-琥珀酰亚胺酯和用官能团衍生的染料掺杂的纳米颗粒。 本发明进一步提供一种制造染料掺杂纳米颗粒的方法，包括以下步骤：通过将染料溶解在表面活性剂己醇中并将染料与有机硅烷共轭，形成油滴中微滴的微乳液，加入染料混合物 到微乳液中，并且向微乳液中加入硅源和催化剂，这导致二氧化硅纳米颗粒掺杂有染料的微乳液的水滴中二氧化硅纳米颗粒的生长。 本发明还在染料掺杂的纳米颗粒中提供了确定染料的重量百分比的方法，其从纳米颗粒产生所需的相对荧光强度。