公开(公告)号：US5182265A

公开(公告)日：1993-01-26

申请号：US562657

申请日：1990-08-03

申请人： Tiberio Bruzzese ,  Massimo Signorini ,  Carlo A. Fanciano ,  Roberta Termini

发明人： Tiberio Bruzzese ,  Massimo Signorini ,  Carlo A. Fanciano ,  Roberta Termini

IPC分类号： A61K38/00 ,  A61P25/04 ,  A61P31/12 ,  A61P37/00 ,  C07K5/08 ,  C07K5/083

CPC分类号： C07K5/0806 ,  C07K5/081 ,  A61K38/00

摘要： Peptide derivatives and their salts with pharmaceutically acceptable acids or bases, having the general formula (I), ##STR1## wherein R=--H, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, alkoxycarbonyl with C.sub.1 -C.sub.4 alkyl;R.sub.1 =--H, C.sub.1 -C.sub.3 alkyl;R.sub.2 =--H, --OH, --OR'.sub.2, wherein R'.sub.2 =C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.3 =--H, --CH.sub.3 ;n=1,2R.sub.4 =--H, --COOH, --CONH.sub.2, --COOR'.sub.4, wherein R'.sub.4 =C.sub.1 -C.sub.3 alkyl, benzyl;R.sub.5 =--H, 4--OH, 3,4--OH, --OR'.sub.5 wherein R'.sub.5 =C.sub.1 -3 alkyl, C.sub.1 -C.sub.3 acyl, benzyl;R.sub.6 =--OH, --NH.sub.2, --OR'.sub.6 wherein R'.sub.6 =C.sub.1 -C.sub.3 alkyl, benzyl; endowed with analgesic, antiviral, immuno-modulating pharmacological properties, and the pharmaceutical forms containing them as active ingredients.