公开(公告)号：US20050250730A1

公开(公告)日：2005-11-10

申请号：US10991634

申请日：2004-11-18

申请人： Michael Yeadon ,  John Watson ,  Roison Armstrong

发明人： Michael Yeadon ,  John Watson ,  Roison Armstrong

IPC分类号： C07H19/167 ,  A61K9/00 ,  A61K31/46 ,  A61K31/52 ,  A61K31/7076 ,  A61K45/06 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P29/00 ,  C07D451/12

CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/008 ,  A61K31/52 ,  A61K31/7076

摘要： A combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (i) an adenosine A2A receptor agonist; and (ii) an anti-cholinergic agent, preferably comprising a member selected from the group consisting of tiotropium and derivatives thereof; the combination being therapeutically effective in the treatment of the diseases when administered by inhalation; as well as to a method of treating the obstructive airways and other inflammatory diseases comprising administering separately, simultaneously or sequentially to the mammal by inhalation a therapeutically effective amount of the combination of therapeutic agents; as well as to a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with the combination of therapeutic agents; as well as to a product containing the compounds of the combination for separate, simultaneous or sequential administration by inhalation to a mammal for the treatment of obstructive airways and other inflammatory diseases. It is preferred that the anti-cholinergic agent component be tiotropium bromide.