公开(公告)号：US20070027193A1

公开(公告)日：2007-02-01

申请号：US10736739

申请日：2004-11-10

申请人： Johann Leban ,  Bernd Kramer ,  Roland Baugartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

发明人： Johann Leban ,  Bernd Kramer ,  Roland Baugartner ,  Katharina Aulinger-Fuchs ,  Stefan Tasler

IPC分类号： A61K31/44 ,  A61K31/401

CPC分类号： A61K31/401 ,  A61K31/44 ,  C07C233/60 ,  C07C2601/10 ,  C07D333/24 ,  Y02A50/411

摘要： The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.