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公开(公告)号：US08361996B2
公开(公告)日：2013-01-29
申请号：US11992141
申请日：2006-09-08
IPC分类号： A61K31/58 , A61K31/565 , A61K31/566 , C07J1/00 , C07J41/00 , C07J43/00
CPC分类号： C07J43/003 , C07D233/54
摘要： The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)
摘要翻译： 本发明提供具有以下一般结构式（A和B）的咪唑基取代的甾体和茚满-1-酮衍生物及其盐的新系列，
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2.发明申请Novel Series of Imidazolyl Substituted Steroidal and Indan-1-One Derivatives 有权咪唑基取代的甾体和茚满-1-酮衍生物的新系列公开(公告)号：US20090137541A1
公开(公告)日：2009-05-28
申请号：US11992141
申请日：2006-09-08
CPC分类号： C07J43/003 , C07D233/54
摘要： The present invention provides a novel series of imidazolyl substituted steroidal and indan-1-one derivatives and salts thereof having the following general structural formulae (A and B)
摘要翻译： 本发明提供具有以下一般结构式（A和B）的咪唑基取代的甾体和茚满-1-酮衍生物及其盐的新系列，
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公开(公告)号：US06559157B2
公开(公告)日：2003-05-06
申请号：US09866179
申请日：2001-05-25
申请人： Rolf Wolfgang Hartmann , Bertil Wachall , Makoto Yoshihama , Masamichi Nakakoshi , Shin Nomoto , Yoshikazu Ikeda
发明人： Rolf Wolfgang Hartmann , Bertil Wachall , Makoto Yoshihama , Masamichi Nakakoshi , Shin Nomoto , Yoshikazu Ikeda
IPC分类号： A61K314409
CPC分类号： C07D233/54 , C07C2602/10 , C07D213/30
摘要： Dihydronaphthalene compounds have excellent 17&agr;-hydroxylase/C17-20-lyase inhibiting activity, thromboxan A2 synthesis inhibiting activity, and aromatase inhibiting activity and are thereby are useful as preventive and/or therapeutic agents for various male sex hormone- and female sex hormone-dependent diseases such as prostate cancer, prostatomegaly, masculinization, breast cancer, mastopathy, uterine cancer, endometriosis, and ovarian cancer, as well as myocardial infarction, angina pectoris, and bronchial asthma.
摘要翻译： 二氢萘化合物具有优异的17α-羟化酶/ C17-20-裂解酶抑制活性，血栓素A2合成抑制活性和芳香酶抑制活性，因此可用作各种男性性激素和雌性激素依赖性的预防和/或治疗剂 诸如前列腺癌，前列腺肥大，男性化，乳腺癌，乳腺病，子宫癌，子宫内膜异位症和卵巢癌以及心肌梗塞，心绞痛和支气管哮喘的疾病。
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