公开(公告)号：US20220296695A1

公开(公告)日：2022-09-22

申请号：US17312442

申请日：2019-12-17

申请人： Chitrananda ABEYGUNAWARDANA ,  Yadong Adam CUI ,  Romulo FERRERO ,  Jian HE ,  Luwy MUSEY ,  Tanaz PETIGARA ,  Julie M. SKINNER ,  Merck Sharp & Dohme Corp.

发明人： Chitrananda Abeygunawardana ,  Yadong Adam Cui ,  Romulo Ferrero ,  Jian He ,  Luwy Musey ,  Tanaz Petigara ,  Julie M. Skinner

IPC分类号： A61K39/09 ,  A61K47/20 ,  A61P31/04 ,  A61P37/04

摘要： The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and/or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.