公开(公告)号：US5552546A

公开(公告)日：1996-09-03

申请号：US282398

申请日：1994-07-28

申请人： Douglas L. Pearson ,  Jon A. Orvik ,  Gary A. Roth ,  Carmen A. Scott ,  Ron B. Leng ,  Dawn L. Shiang

发明人： Douglas L. Pearson ,  Jon A. Orvik ,  Gary A. Roth ,  Carmen A. Scott ,  Ron B. Leng ,  Dawn L. Shiang

IPC分类号： C07D239/60 ,  C07D239/02

CPC分类号： C07D239/60

摘要： A salt of 2-ethoxy-4,6-dihydroxypyrimidine (DHEP) is prepared by contacting a salt of O-ethylisourea with dimethyl malonate in the presence of a methoxide base to form the salt of DHEP. The salt of DHEP can optionally be protonated with an acid to form neutral DHEP. The reaction is typically conducted in a methanol solvent at a temperature less than about 30.degree. C. Typically, the monosodium salt of DHEP is prepared by contacting O-ethylisourea hydrochloride with dimethyl malonate in the presence of sodium methoxide and methanol solvent.

摘要翻译： 通过在甲醇盐碱存在下使O-乙基异脲的盐与丙二酸二甲酯接触以制备DHEP的盐来制备2-乙氧基-4,6-二羟基嘧啶（DHEP）的盐。 DHEP的盐可任选地用酸质子化形成中性DHEP。 反应通常在甲醇溶剂中在低于约30℃的温度下进行。通常，在甲醇钠和甲醇溶剂存在下，通过使O-乙基异脲盐酸盐与丙二酸二甲酯接触来制备DHEP的单钠盐。