公开(公告)号：US06200786B1

公开(公告)日：2001-03-13

申请号：US09391785

申请日：1999-09-08

申请人： Rongmin Huang ,  Philip A. Christenson ,  Ivica M. Labuda

发明人： Rongmin Huang ,  Philip A. Christenson ,  Ivica M. Labuda

IPC分类号： C12P700

CPC分类号： C12P7/26 ,  C12P7/00

摘要： A method of producing nootkatone by laccase catalyzed oxidation of valencene. Valencene and a composition having laccase activity are reacted in the presence of an oxygen source, at a valencene concentration greater than 0.1%, to form valencene hydroperoxide. Optionally, a mediator and/or a solvent at a concentration that maintains laccase activity may also be included. The valencene hydroperoxide is degraded to form nootkatone, and nootkatone is then recovered. The method produces nootkatone in commercially viable yields.

摘要翻译： 通过漆酶催化氧化戊烯生产诺卡酮的方法。 戊烯和具有漆酶活性的组合物在氧源的存在下以大于0.1％的戊烯浓度反应，形成氢过氧化戊酸。 任选地，还可以包括维持漆酶活性浓度的介体和/或溶剂。 戊烯氢过氧化物被降解形成诺卡酮，然后回收诺塔卡酮。 该方法以商业上可行的收率产生诺塔卡酮。