公开(公告)号：US07598067B2

公开(公告)日：2009-10-06

申请号：US11421658

申请日：2006-06-01

申请人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

发明人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

IPC分类号： C12N15/79 ,  C12N15/80 ,  C12N15/81 ,  C12N9/16 ,  C12Q1/68

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

摘要翻译： 本发明提供编码本发明的新型PDE蛋白的分离的全长核酸分子及其用途的方法。 本发明的核酸分子还包括与本发明的核酸分子反应的肽核酸（PNA）和反义分子。 本发明还涉及新型PDE蛋白的活性的激动剂，抗体，拮抗剂或抑制剂。 这些组合物可用于诊断，预防或治疗与新型PDE蛋白的存在或不足相关的病症。

公开(公告)号：US20070116705A1

公开(公告)日：2007-05-24

申请号：US11421658

申请日：2006-06-01

申请人： Joseph Beavo ,  Thomas Seebeck ,  Scott Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

发明人： Joseph Beavo ,  Thomas Seebeck ,  Scott Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

IPC分类号： A61K39/395 ,  A61K31/519 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

摘要翻译： 本发明提供编码本发明的新型PDE蛋白的分离的全长核酸分子及其用途的方法。 本发明的核酸分子还包括与本发明的核酸分子反应的肽核酸（PNA）和反义分子。 本发明还涉及新型PDE蛋白的活性的激动剂，抗体，拮抗剂或抑制剂。 这些组合物可用于诊断，预防或治疗与新型PDE蛋白的存在或不足相关的病症。

公开(公告)号：US07138259B2

公开(公告)日：2006-11-21

申请号：US10380437

申请日：2001-09-12

申请人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

发明人： Joseph A. Beavo ,  Thomas Seebeck ,  Scott Haydn Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewei Gong ,  Natalie Glavas

IPC分类号： C12N9/16 ,  C12N15/79 ,  C12N15/80 ,  C12N15/81 ,  C12Q1/68

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

公开(公告)号：US20050058998A1

公开(公告)日：2005-03-17

申请号：US10380437

申请日：2001-09-12

申请人： Joseph Beavo ,  Thomas Seebeck ,  Scott Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewen Gong ,  Natalie Glavas

发明人： Joseph Beavo ,  Thomas Seebeck ,  Scott Soderling ,  Ana Rascon ,  Roya Zoraghi ,  Stefan Kunz ,  Kewen Gong ,  Natalie Glavas

IPC分类号： A61K38/00 ,  C07H21/04 ,  C12N9/16 ,  C12N15/55 ,  C12Q1/68

CPC分类号： C07H21/04 ,  A61K38/00 ,  C12N9/16 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

摘要翻译： 本发明提供了编码本发明的新型PDE蛋白的分离的全长核酸分子及其用途的方法。 本发明的核酸分子还包括与本发明的核酸分子反应的肽核酸（PNA）和反义分子。 本发明还涉及新型PDE蛋白的活性的激动剂，抗体，拮抗剂或抑制剂。 这些组合物可用于诊断，预防或治疗与新型PDE蛋白的存在或不足相关的病症。