公开(公告)号：US20120183953A1

公开(公告)日：2012-07-19

申请号：US13096408

申请日：2011-04-28

Applicant: Nianqing XIAO ,  John K. HENKHAUS ,  Bin ZHU ,  Deacon SWEENEY ,  Thomas ANANTHARAMAN ,  Ryan PTASHKIN

Inventor： Nianqing XIAO ,  John K. HENKHAUS ,  Bin ZHU ,  Deacon SWEENEY ,  Thomas ANANTHARAMAN ,  Ryan PTASHKIN

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6869 ,  C12Q2521/301 ,  C12Q2523/31 ,  C12Q2565/601

Abstract: The invention generally relates to methods for assembling sequence contigs. In certain embodiments, methods of the invention involve converting sequence contigs into maps, generating a plurality of single molecule restriction maps, aligning single molecule restriction maps to ends of the maps of the sequence contigs, thereby producing extended sequence contigs, and aligning extended sequence contigs.

Abstract translation: 本发明一般涉及组装序列重叠群的方法。 在某些实施方案中，本发明的方法涉及将序列重叠群转化为图，产生多个单分子限制性图谱，将单分子限制图谱对准序列重叠群的图的末端，从而产生扩增序列重叠群，并对齐扩增序列重叠群 。