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公开(公告)号：US11767312B2
公开(公告)日：2023-09-26
申请号：US18131309
申请日：2023-04-05
发明人： Hongfu Lu , Weiqiang Xing , Yongcong Lv , Baojian Qi , Jianbiao Peng , Haibing Guo
IPC分类号： C07D401/14 , C07D487/08 , A61P35/00
CPC分类号： C07D401/14 , A61P35/00 , C07D487/08 , C07B2200/07
摘要： Disclosed are a phthalazinone compound, and a preparation method therefor and the medical use thereof. In particular, disclosed are a compound as represented by formula (I), and a pharmacodynamically acceptable salt, and the use of the compound as an androgen receptor (AR) for degradation.
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公开(公告)号：US12122787B2
公开(公告)日：2024-10-22
申请号：US18101515
申请日：2023-01-25
发明人： Shuchun Guo , Jun Fan , Yang Liu , Fang Bao , Jianbiao Peng , Haibing Guo
IPC分类号： C07D471/22 , A61P35/00 , C07D471/14 , C07D498/14 , C07D498/22
CPC分类号： C07D498/22 , A61P35/00 , C07D471/14 , C07D471/22 , C07D498/14
摘要： Disclosed in the present invention are a fused pyridone compound, and a preparation method therefor and a use thereof. Specifically, the present invention discloses a compound of formula (I-B), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.
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公开(公告)号：US20220251095A1
公开(公告)日：2022-08-11
申请号：US17621901
申请日：2020-06-28
发明人： Shuchun GUO , Jiangwei WANG , Shan YAO , Yong ZHANG , Zhangping KANG , Qiong ZHANG , Yan YE , Jianbiao PENG , Haibing GUO
IPC分类号： C07D487/04 , C07D471/04
摘要： A compound represented by formula (I), an optical isomer thereof and a pharmaceutically acceptable salt thereof, as well as an application of said compound as an FXIa inhibitor.
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公开(公告)号：US20230111119A1
公开(公告)日：2023-04-13
申请号：US17788154
申请日：2020-12-23
发明人： Hongfu LU , Weiqiang XING , Baojian QI , Jianbiao PENG , Haibing GUO
IPC分类号： C07D401/14 , A61P35/00 , A61P25/28 , A61P15/00
摘要： Provided are a protein degradation agent compound preparation method and application; specifically, provided are the compound represented by formula (I) and a pharmacologically acceptable salt thereof, and an application of said compound in the degradation of androgen receptor (AR).
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公开(公告)号：US20220298174A1
公开(公告)日：2022-09-22
申请号：US17632167
申请日：2020-08-03
发明人： Shuchun GUO , Jun FAN , Yang LIU , Jianbiao PENG , Haibing GUO
IPC分类号： C07D498/16 , C07D498/22 , C07D471/04 , A61P35/00
摘要： Disclosed are a compound as shown in formula (I), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.
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公开(公告)号：US20210340169A1
公开(公告)日：2021-11-04
申请号：US17284154
申请日：2019-10-12
发明人： Shuchun GUO , Jianbiao PENG , Yang LIU , Haibing GUO
IPC分类号： C07H19/213 , A61P35/00
摘要： Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.
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公开(公告)号：US20230227472A1
公开(公告)日：2023-07-20
申请号：US18101515
申请日：2023-01-25
发明人： Shuchun GUO , Jun FAN , Yang LIU , Fang BAO , Jianbiao PENG , Haibing GUO
IPC分类号： C07D498/22 , A61P35/00 , C07D471/14 , C07D471/22 , C07D498/14
CPC分类号： C07D498/22 , A61P35/00 , C07D471/14 , C07D471/22 , C07D498/14
摘要： Disclosed in the present invention are a fused pyridone compound, and a preparation method therefor and a use thereof. Specifically, the present invention discloses a compound of formula (I-B), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.
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公开(公告)号：US20220389029A1
公开(公告)日：2022-12-08
申请号：US17761983
申请日：2020-09-21
发明人： Shuchun GUO , Jun FAN , Yang LIU , Fang BAO , Jianbiao PENG , Haibing GUO
IPC分类号： C07D498/22 , C07D471/22 , C07D471/14 , C07D498/14 , A61P35/00
摘要： Disclosed in the present invention are a fused pyridone compound, and a preparation method therefor and a use thereof. Specifically, the present invention discloses a compound of formula (I-B), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a KRAS inhibitor.
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公开(公告)号：US20220267364A1
公开(公告)日：2022-08-25
申请号：US17629522
申请日：2020-07-24
发明人： Jianbiao PENG , Shuchun GUO , Yang LIU , Haibing GUO
IPC分类号： C07H15/26 , C07D403/14 , C07D471/10 , C07D491/107 , A61P35/00
摘要： Disclosed in the present invention are a compound shown in formula (IA), an optical isomer thereof and a pharmaceutically acceptable salt thereof, and the use of the compound as a STING agonist.
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公开(公告)号：US20220017513A1
公开(公告)日：2022-01-20
申请号：US17299515
申请日：2019-12-06
发明人： Hongfu LU , Jianbiao PENG , Weiqiang XING , Haibing GUO
IPC分类号： C07D471/04 , C07D209/18 , C07D235/16 , C07D277/64 , C07D263/56 , C07D401/12 , C07D405/12
摘要： Relating to a compound represented by formula (I) and a pharmaceutically acceptable salt of the compound, and an application of the compound as an S1P1 agonist.
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