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11 条记录 (耗时 0.014 秒)

    CRYSTAL FORM OF GONADOTROPIN RELEASING HORMONE ANTAGONIST, PREPARATION METHOD THEREFOR, AND USE THEREOF
    8.
    发明申请
    CRYSTAL FORM OF GONADOTROPIN RELEASING HORMONE ANTAGONIST, PREPARATION METHOD THEREFOR, AND USE THEREOF 有权

    公开(公告)号：US20220169658A1

    公开(公告)日：2022-06-02

    申请号：US17675576

    申请日：2022-02-18

    申请人： Shenzhen Rentai Pharmatech Ltd.

    发明人： Guobin Ren ,  Weijie Ji ,  Dongxu Yi ,  Jiajun Huang

    IPC分类号： C07D495/04

    摘要： Provided are a crystal form of a gonadotropin releasing hormone antagonist, a preparation method therefor, and use thereof. A crystal form C and a crystal form D have high purity, good illumination stability, high temperature stability, and high humidity stability, and have good solubility and low hygroscopicity; the saturation solubility of the crystal form C and the crystal form D is 101.75 μg/ml and 87.21 μg/ml, respectively; when the relative humidity is increased from 0 to 50% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 1.76% and 0.73%, respectively; and when the relative humidity is increased from 0 to 90% RH, the hygroscopy gain of the crystal form C and the crystal form D is not greater than 3.43% and 1.61%, respectively. Therefore, the control of a production condition is facilitated, the preparation process is simple, the quality is stable, and large-scale industrial production is easy.

    EUTECTIC FORM A OF ELAGOLIX AND PYRIMETHAMINE, PREPARATION METHOD THEREFOR AND USE THEREOF
    9.
    发明申请
    EUTECTIC FORM A OF ELAGOLIX AND PYRIMETHAMINE, PREPARATION METHOD THEREFOR AND USE THEREOF 有权

    公开(公告)号：US20220143019A1

    公开(公告)日：2022-05-12

    申请号：US17586160

    申请日：2022-01-27

    申请人： Shenzhen Rentai Pharmatech Ltd.

    发明人： Guobin Ren ,  Weijie Ji ,  Dongxu Yi ,  Jiajun Huang

    IPC分类号： A61K31/513 ,  A61K31/505

    摘要： Disclosed are eutectic form A of Elagolix and pyrimethamine, a preparation method therefor and a use thereof. Using Cu-Kα radiation, eutectic form A has characteristic peaks represented by a 20 degree at 8.1±0.2°, 12.2±0.2°, 13.3±0.2° and 21.1±0.2° in an X-ray powder diffraction. Eutectic form A has a high purity, a good light radiation stability, a high temperature stability, a high humidity stability and an accelerated stability, is easy to store, and has a slow moisture absorption under the condition of relatively low humidity, wherein the weight gain of eutectic form A by moisture absorption is not more than 1.08% when the relative humidity increases from 0 to 60% RH. Production conditions for eutectic form A are easy to control, same has a simple preparation process and a stable quality, and is easy to industrially produce on a large-scale.