公开(公告)号：US20090156837A1

公开(公告)日：2009-06-18

申请号：US12338467

申请日：2008-12-18

申请人： Dinesh Shantilal PATEL ,  Sachin Dinesh Patel ,  Shashikant Prabhudas Kurani ,  Tapas Barui ,  Rajneesh Anand ,  T. Damodar Reddy

发明人： Dinesh Shantilal PATEL ,  Sachin Dinesh Patel ,  Shashikant Prabhudas Kurani ,  Tapas Barui ,  Rajneesh Anand ,  T. Damodar Reddy

IPC分类号： C07D309/30

CPC分类号： C07D309/30

摘要： The present invention relates to a novel process for isolation and recovery of compounds such as biosynthetically produced simvastatin in either lactone form or in the form of its acid salt in high yield and purity, from microbial fermentation broth and isolating the said statin from harvested microbial broth.

摘要翻译： 本发明涉及从微生物发酵液中分离和回收化合物如生物合成生产的辛伐他汀或其内酯形式或其酸盐形式的高产率和纯度的新方法，并从收获的微生物肉汤中分离所述他汀类 。

公开(公告)号：US06589973B1

公开(公告)日：2003-07-08

申请号：US10146674

申请日：2002-05-15

申请人： Dinesh Shantilal Patel ,  Sachin Dinesh Patel ,  Shashikant Prabhudas Kurani

发明人： Dinesh Shantilal Patel ,  Sachin Dinesh Patel ,  Shashikant Prabhudas Kurani

IPC分类号： A61K31415

CPC分类号： A61K47/26 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/08

摘要： A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising because of cyclooxygenase-2 activity. In particular the pharmaceutical preparation of COX 2 inhibitors comprise of selective active COX 2 inhibitors selected from Celeoxib, Rofecoxib and their analogs dissolved in a selective isosorbide type solvent of following general formula I where R1 and R2 are hydrogen or alkyl chains containing 1-3 carbons or acetate group. Also disclosed is a simple and cost effective process of manufacture of the above novel pharmaceutical preparation.

摘要翻译： 一种用于治疗由于环氧合酶-2活性引起的疼痛和炎症状态的肠胃外形式的选择性环加氧酶II抑制剂（COX 2）抑制剂的清晰，稳定的新型药物制剂。 特别地，COX 2抑制剂的药物制剂包含选自活性COX 2抑制剂，其选自塞来昔布，罗非昔布及其类似物，其溶解于以下通式I的选择性异山梨醇型溶剂中，其中R 1和R 2为氢或含有1-3个碳的烷基链或 乙酸酯基。 还公开了制备上述新型药物制剂的简单且成本有效的方法。