公开(公告)号：US20230063427A1

公开(公告)日：2023-03-02

申请号：US17900740

申请日：2022-08-31

申请人： Tatyana I. Igumenova ,  Sachin S. Katti

发明人： Tatyana I. Igumenova ,  Sachin S. Katti

IPC分类号： C07K1/30 ,  C30B7/00 ,  C30B29/58

摘要： A crystallization method for making high-quality molecular crystals containing complexes of diacylglycerol (DAG)-effector proteins and ligands thereof. For example, some of such crystals are of a quality sufficient for crystal-structure determination by X-ray crystallography with a spatial resolution of at least 3.0 Å or, in some cases, of about 1 Å. At least some embodiments of the crystallization method and of the molecular crystals produced thereby can beneficially be used, e.g., to provide high-resolution guides for the design and development of exogenous agonists of DAG-effector proteins of therapeutic interest.