公开(公告)号：US20170056510A1

公开(公告)日：2017-03-02

申请号：US14917387

申请日：2016-03-08

申请人： Dinesh U. Chimmanamada ,  Weiwen Ying ,  Junyi Zhang ,  Teresa Kowalczyk-Przewloka ,  Jun Jiang ,  Sami Osman ,  Genliang Lu ,  Dharma Vutukuri ,  James Loch ,  Shoujun Chen

发明人： Dinesh U. Chimmanamada ,  Weiwen Ying ,  Junyi Zhang ,  Teresa Kowalczyk-Przewloka ,  Jun Jiang ,  Sami Osman ,  Genliang Lu ,  Dharma Vutukuri ,  James Loch ,  Shoujun Chen

IPC分类号： A61K47/48 ,  A61K31/454 ,  A61K31/519 ,  A61K31/513 ,  A61K31/4184 ,  A61K31/167 ,  A61K31/58 ,  A61K31/4545 ,  A61K31/704 ,  A61K31/497 ,  A61K31/42 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/506 ,  A61K31/565 ,  A61K38/05 ,  A61K31/4745

摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.