公开(公告)号：US20170159102A1

公开(公告)日：2017-06-08

申请号：US15169215

申请日：2016-05-31

申请人： San Diego State University (SDSU) Foudation, dba San Diego State University Research Foundation

发明人： Roland Wolkowicz

IPC分类号： C12Q1/37

CPC分类号： C12Q1/37 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/03 ,  C12N9/506 ,  C12N2503/02 ,  C12N2510/00 ,  C12Y304/23016 ,  G01N33/5076 ,  G01N2333/9513 ,  G01N2500/02 ,  G01N2500/10

摘要： The invention is directed to compositions to screen for small molecule drugs that inhibit proteases, such as viral proteases, e.g., HIV proteases; and methods for making and using these compositions. The invention provides compositions and methods for identifying compositions, e.g., drug molecules, that can inhibit proteases, e.g., HIV proteases. In alternative embodiments, the invention provides cell-based assays to screen for compositions, e.g., small molecules or drugs, that inhibit or modify the activity of enzymes such as calcium-dependent protein convertases involved in HIV envelop protein processing, including cleavage of the HIV gp160 envelope precursor, resulting in gp120 and gp41 envelope products.