公开(公告)号：US06384281B1

公开(公告)日：2002-05-07

申请号：US09958218

申请日：2001-10-03

申请人： Martine Keenan ,  Sandra Ginette Milutinovic ,  David Edward Tupper

发明人： Martine Keenan ,  Sandra Ginette Milutinovic ,  David Edward Tupper

IPC分类号： A61K3144

CPC分类号： C07C233/58 ,  C07C211/30 ,  C07C215/64 ,  C07C217/74 ,  C07C2602/20 ,  C07C2602/22 ,  C07D209/14 ,  C07D209/18 ,  C07D333/60

摘要： A pharmaceutical compound of formula (I) in which R1 and R2 are each hydrogen or C1-4 alkyl, or R1 and R2 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, or morpholino group, said group being optionally substituted with 1 to 3 C1-4alkyl substituents, R3 is a naphythyl, indolyl, benzothienyl, benzofuranyl, benzothiazolyl, quinolinyl or isoquinolinyl group, said group being optionally substituted, and n is 1 or 2; or a salt or ester thereof.

摘要翻译： 式（I）的药物化合物，其中R 1和R 2各自为氢或C 1-4烷基，或R 1和R 2与它们所连接的氮原子一起形成氮杂环丁烷基，吡咯烷基，哌啶基，哌嗪基或吗啉代基， 所述基团任选被1至3个C 1-4烷基取代基取代，R 3是萘基，吲哚基，苯并噻吩基，苯并呋喃基，苯并噻唑基，喹啉基或异喹啉基，所述基团任选被取代，n是1或2; 或其盐或酯。