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公开(公告)号:US20130272959A1
公开(公告)日:2013-10-17
申请号:US13994783
申请日:2011-12-16
申请人: Raffaella Rossin , Tilman Laeppchen , Sandra Martina Van Den Bosch , Marc Stefan Robillard , Ronny Mathieu Versteegen
发明人: Raffaella Rossin , Tilman Laeppchen , Sandra Martina Van Den Bosch , Marc Stefan Robillard , Ronny Mathieu Versteegen
CPC分类号: A61K51/044 , A61K31/495 , A61K45/06 , A61K47/4873 , A61K47/48746 , A61K47/6893 , A61K47/6897 , A61K51/0495 , A61K51/1027 , A61K51/1045 , A61K51/1093 , B82Y5/00
摘要: Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.
摘要翻译: 描述了一种方法,以及其中使用的试剂的组合,通过其可以将施用于受试者的药剂迅速地从循环中清除。 这通过提供与反应性基团的给药剂(例如用于预靶向的探针)并向澄清剂提供另一反应性基团来实现,所述反应性基团形成生物正交反应性对。 优选地,反应性对包括作为一种反应物的环辛烯或环辛烯,和作为其它反应物的二烯。 该方法和组合可用于从循环中除去任何可结合的分子,例如在预靶向法,靶向或成像剂递送过程中过量的预靶向探针,或去除任何生物分子 已经流通。
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公开(公告)号:US20130189184A1
公开(公告)日:2013-07-25
申请号:US13877725
申请日:2011-10-11
申请人: Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
发明人: Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
IPC分类号: A61K51/10
CPC分类号: A61K51/1093 , A61K47/6889 , A61K47/6891 , A61K49/16 , A61K51/0495 , A61K51/10 , B82Y5/00
摘要: Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.
摘要翻译: 描述了用于靶向医学成像和/或治疗剂的预靶向方法和相关试剂盒,其中使用对彼此显示出生物正交反应性的非生物反应性化学基团。 本发明涉及使用[4 + 2]反电子需求(复古)Diels-Alder化学来提供预瞄准探针和效应探针之间的耦合。 为此目的,这些探针中的一个包括电子缺乏四嗪或其它合适的二烯,另一个是具有一个或多个轴取代基的E-环辛烯。
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公开(公告)号:US09427482B2
公开(公告)日:2016-08-30
申请号:US13994783
申请日:2011-12-16
申请人: Raffaella Rossin , Tilman Laeppchen , Sandra Martina Van Den Bosch , Marc Stefan Robillard , Ronny Mathieu Versteegen
发明人: Raffaella Rossin , Tilman Laeppchen , Sandra Martina Van Den Bosch , Marc Stefan Robillard , Ronny Mathieu Versteegen
IPC分类号: A61K51/00 , A61M36/14 , A61K51/04 , A61K47/48 , A61K51/10 , B82Y5/00 , A61K45/06 , A61K31/495
CPC分类号: A61K51/044 , A61K31/495 , A61K45/06 , A61K47/4873 , A61K47/48746 , A61K47/6893 , A61K47/6897 , A61K51/0495 , A61K51/1027 , A61K51/1045 , A61K51/1093 , B82Y5/00
摘要: Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.
摘要翻译: 描述了一种方法,以及其中使用的试剂的组合,通过其可以将施用于受试者的药剂迅速地从循环中清除。 这通过提供与反应性基团的给药剂(例如用于预靶向的探针)并向澄清剂提供另一反应性基团来实现,所述反应性基团形成生物正交反应性对。 优选地,反应性对包括作为一种反应物的环辛烯或环辛烯,和作为其它反应物的二烯。 该方法和组合可用于从循环中除去任何可结合的分子,例如在预靶向法,靶向或成像剂递送过程中过量的预靶向探针,或去除任何生物分子 已经流通。
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公开(公告)号:US09463256B2
公开(公告)日:2016-10-11
申请号:US13877725
申请日:2011-10-11
申请人: Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
发明人: Johan Lub , Wolter Ten Hoeve , Raffaella Rossin , Sandra Martina Van Den Bosch , Marc Stefan Robillard
CPC分类号: A61K51/1093 , A61K47/6889 , A61K47/6891 , A61K49/16 , A61K51/0495 , A61K51/10 , B82Y5/00
摘要: Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.
摘要翻译: 描述了用于靶向医学成像和/或治疗剂的预靶向方法和相关试剂盒,其中使用对彼此显示出生物正交反应性的非生物反应性化学基团。 本发明涉及使用[4 + 2]反电子需求(复古)Diels-Alder化学来提供预瞄准探针和效应探针之间的耦合。 为此目的,这些探针中的一个包括电子缺乏四嗪或其它合适的二烯,另一个是具有一个或多个轴取代基的E-环辛烯。
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