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公开(公告)号：US20100099667A1
公开(公告)日：2010-04-22
申请号：US12410425
申请日：2009-03-24
Applicant: David T. Hung , Andrew Asher Protter , Sarjavit Chakravarty , Rajendra Parasmal Jain
Inventor： David T. Hung , Andrew Asher Protter , Sarjavit Chakravarty , Rajendra Parasmal Jain
IPC: A61K31/541 , C07D471/08 , C07D279/12 , C07D413/14 , A61K31/439 , A61K31/5377 , A61P25/18 , A61P25/28
CPC classification number: C07D451/00 , C07D471/08 , C07D471/18
Abstract: This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
Abstract translation: 本公开涉及可用于调节个体中组胺受体的新化合物。 描述了新的化合物，包括新的桥连杂环[4,3-b]吲哚化合物。 还提供药物组合物。 还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。
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公开(公告)号：US5817756A
公开(公告)日：1998-10-06
申请号：US401595
申请日：1995-03-09
Applicant: Donald James Kyle , Babu Joseph Mavunkel , Sarjavit Chakravarty , Zhijian Lu
Inventor： Donald James Kyle , Babu Joseph Mavunkel , Sarjavit Chakravarty , Zhijian Lu
Abstract: The invention provides bradykinin antagonist compounds wherein many (or all) of the peptide bonds of bradykinin are eliminated to yield compounds which specifically compete with bradykinin for binding to the bradykinin receptor. More particularly, the invention relates to compounds having, in appropriate spatial arrangement, two positively charged moieties flanking a hydrophobic organic moiety and a moiety which mimics a beta turn conformation.
Abstract translation: 本发明提供缓激肽拮抗剂化合物，其中消除缓激肽的许多（或全部）肽键，以产生与缓激肽特异性竞争结合缓激肽受体的化合物。 更具体地说，本发明涉及在适当的空间排列中具有侧翼于疏水性有机部分的两个带正电荷的部分和模拟β转角构象的部分的化合物。
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