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公开(公告)号:US20130064788A1
公开(公告)日:2013-03-14
申请号:US13501244
申请日:2010-10-11
申请人: Thomas M. Barnes , Michael M. Schmidt , Bracken M. King , K. Christopher Garcia , Sashank Reddy , Gregory James Sieczkiewicz , Lauren K. Ely
发明人: Thomas M. Barnes , Michael M. Schmidt , Bracken M. King , K. Christopher Garcia , Sashank Reddy , Gregory James Sieczkiewicz , Lauren K. Ely
IPC分类号: A61K38/20 , C12P21/02 , C12N5/10 , C12N1/21 , A61P29/00 , C12N1/19 , C07K14/54 , C07K16/24 , C07H21/04 , A61P37/02 , A61K39/395 , C12N1/15
CPC分类号: C07K14/54 , C07K14/7155
摘要: Binding proteins, including non-naturally occurring and recombinantly modified proteins that bind to an IL-17R and including proteins having a mutated IL-17 cytokine sequence, methods of making such molecules and methods of using such molecules as therapeutic, prophylactic and diagnostic agents are provided.
摘要翻译: 结合蛋白质,包括结合IL-17R的非天然存在和重组修饰的蛋白质,并且包括具有突变的IL-17细胞因子序列的蛋白质,制备这种分子的方法和使用这些分子作为治疗剂,预防剂和诊断剂的方法是 提供。