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1.发明申请METHODS AND COMPOSITIONS FOR DELIVERY OF TAXANES IN STABLE OIL-IN-WATER EMULSIONS 审中-公开在稳定的水包油乳剂中输送紫杉醇的方法和组合物公开(公告)号：US20110166214A1
公开(公告)日：2011-07-07
申请号：US12986909
申请日：2011-01-07
IPC分类号： A61K31/337 , A61K8/02 , A61P35/04
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/1075 , A61K47/24 , A61K47/44
摘要： The present invention provides methods and compositions for delivery of taxanes in stable oil-in-water emulsion. The inventive emulsion formulation includes an oil phase, aqueous and emulsifier phases. The oil portion includes all or substantial amount of taxane, vegetable oil and medium chain triglycerides; aqueous phase includes an emulsion stabilizer; emulsifier phase reduces the surface tension between oil and aqueous phases to produce a stable oil-in-water emulsion. The inventive compositions produce minimal side effects upon administration.
摘要翻译： 本发明提供了用于在稳定的水包油乳液中递送紫杉烷的方法和组合物。 本发明的乳液制剂包括油相，水相和乳化剂相。 油部分包括所有或大量的紫杉烷，植物油和中链甘油三酯; 水相包括乳液稳定剂; 乳化剂相降低油和水相之间的表面张力，以产生稳定的水包油乳液。 本发明组合物在施用时产生最小的副作用。
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公开(公告)号：US06528540B2
公开(公告)日：2003-03-04
申请号：US10016260
申请日：2001-10-30
申请人： Jie Liu , Satish K. Pejaver , George Owoo
发明人： Jie Liu , Satish K. Pejaver , George Owoo
IPC分类号： A61K3124
CPC分类号： A61K31/215 , A61K9/0019 , A61K31/24 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26
摘要： An aqueous, sterile pharmaceutical composition suitable for parenteral administration for the treatment of cardiac conditions, comprising methyl-3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol hydrochloride), a buffering agent and an osmotic-adjusting agent, as well as a method for its manufacture, are disclosed.
摘要翻译： 包含甲基-3- [4-（2-羟基-3-异丙基氨基）丙氧基]苯基丙酸盐酸盐（盐酸艾司洛尔）），缓冲剂和渗透压差的适用于肠胃外给药的水性无菌药物组合物， 调节剂，以及其制造方法。
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公开(公告)号：US6100302A
公开(公告)日：2000-08-08
申请号：US286159
申请日：1999-04-05
CPC分类号： A61K31/05 , A61K9/1075 , Y10S514/816 , Y10S514/938
摘要： Formulations of intravenous anesthetic propofol emulsions are provided which contain sufficiently low concentrations of soybean oil to produce a stable emulsion and simultaneously provide reduced nutrients, which inhibit microbial growth thereby providing protection against accidental microbial contamination during long-term IV infusions. In addition to the inhibition of microbial growth due to a reduction of nutrients, the formulation exhibits unanticipated additional microbial inhibition due to an increased availability of propofol. The low concentration of soybean oil also provides a formulation that reduces the chances of fat overload when administered over an extended period of time to chronically ill patients.
摘要翻译： 提供静脉麻醉丙泊酚乳剂的制剂，其含有足够低浓度的大豆油以产生稳定的乳液，同时提供减少的营养物质，其抑制微生物生长，从而在长期IV输注期间提供防止意外的微生物污染的保护。 除了由于营养物质的减少而抑制微生物生长之外，由于异丙酚的可用性的增加，该制剂表现出意外的另外的微生物抑制。 低浓度的大豆油也提供了一种配方，可以在延长的时间内长期服用长期患者时，减少脂肪过量的机会。
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公开(公告)号：US06310094B1
公开(公告)日：2001-10-30
申请号：US09759547
申请日：2001-01-12
申请人： Jie Liu , Satish K. Pejaver , George Owoo
发明人： Jie Liu , Satish K. Pejaver , George Owoo
IPC分类号： A61K3124
CPC分类号： A61K31/215 , A61K9/0019 , A61K31/24 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A ready-to-use injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions, comprising methyl-3-[4-(2-hydroxy-3-isopropylamino) propoxy] phenylpropionate hydrochloride (esmolol hydrochloride), a buffering agent and an osmotic-adjusting agent, as well as a method for its manufacture in a container, is disclosed.
摘要翻译： 包含甲基-3- [4-（2-羟基-3-异丙基氨基）丙氧基]苯丙酸酯盐酸盐（盐酸艾司洛尔）），缓冲剂和渗透性的即用型可注射的水性药物组合物 公开了一种调节剂，以及其在容器中的制造方法。
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