公开(公告)号：US20060216360A1

公开(公告)日：2006-09-28

申请号：US11245141

申请日：2005-10-06

Applicant: Satish Upadhyay ,  Manoj Pananchukunnath ,  Dinesh Kumar ,  Ajeet Singh ,  Rama Mukherjee ,  Anand Burman

Inventor： Satish Upadhyay ,  Manoj Pananchukunnath ,  Dinesh Kumar ,  Ajeet Singh ,  Rama Mukherjee ,  Anand Burman

IPC: A61K33/24 ,  A61K31/282

CPC classification number: A61K33/24 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/282 ,  A61K31/555

Abstract: A pharmaceutical composition comprising a platinum (II) complex compound in n aqueous solvent. The pharmaceutical composition is prepared by the essential steps of: (i) adding a platinum (II) complex compound to an oxygen enriched aqueous solvent to obtain a solution; (ii) Sterilizing the solution (iii) Filling the sterilizedsolution of step (ii) into suitable containers; and (iv) Sealing the containers. The oxygen enriched aqueous solvent is obtained by purging or bubbling of a gas into an aqueous solvent for 30 to 150 minutes. A device for preparing the pharmaceutical composition is illustrated in FIG. 1. The composition is used for treatment of a human or an animal cancerous disease by the administration of pharmaceutical compositions of platinum (II) complex compounds as per the claim 1, to the human or animal in need of said treatment.

Abstract translation: 一种包含在n水溶液中的铂（II）络合物化合物的药物组合物。 药物组合物通过以下步骤制备：（i）向富氧水溶剂中加入铂（II）络合物，得到溶液; （ii）灭菌溶液（iii）将步骤（ii）的无菌溶液装入合适的容器中; 和（iv）密封容器。 通过将气体吹扫或鼓泡到含水溶剂中30至150分钟来获得富氧水溶剂。 用于制备药物组合物的装置在图1中示出。 1.通过将权利要求1的铂（II）配合物化合物的药物组合物给予需要所述治疗的人或动物，该组合物用于治疗人或动物癌性疾病。

公开(公告)号：US20070054957A1

公开(公告)日：2007-03-08

申请号：US11515553

申请日：2006-09-05

Applicant: Satish Upadhyay ,  Manoj Pananchukunnath ,  Ajeet Singh ,  Deepti Jain ,  Deepak Parshotamdas ,  Rama Mukharjee ,  Anand Burman

Inventor： Satish Upadhyay ,  Manoj Pananchukunnath ,  Ajeet Singh ,  Deepti Jain ,  Deepak Parshotamdas ,  Rama Mukharjee ,  Anand Burman

IPC: A61K31/282 ,  A61K31/70 ,  A61K31/7012

CPC classification number: A61K47/26 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/70 ,  A61K31/7012

Abstract: A storage stable pharmaceutical composition comprising a solution of Oxaliplatin in water and a catalytic amount of a carbohydrate. A process for forming such pharmaceutical composition comprising dissolving a known amount of Oxaliplatin in water; adding an amount of carbohydrate in the range of 0.0010% to 0.05% w/v with respect to such solution; agitating the mixture to get clear solution; filtering it through a filter membrane under aseptic conditions; and filling the solution resulting into glass vials sealed with elastomeric stoppers and aluminium flip-off seals.

Abstract translation: 一种储存稳定的药物组合物，其包含奥沙利铂在水中的溶液和催化量的碳水化合物。 一种形成这种药物组合物的方法，包括将已知量的奥沙利铂溶于水中; 相对于这种溶液加入0.001-0.05％w / v范围内的碳水化合物量; 搅拌混合物以得到澄清溶液; 在无菌条件下通过滤膜过滤; 并将溶液填充到用弹性塞子和铝翻盖密封件密封的玻璃小瓶中。