公开(公告)号：US08148427B2

公开(公告)日：2012-04-03

申请号：US12525364

申请日：2008-01-31

申请人： Ryoji Hayashi ,  Tsukasa Kikuchi ,  Masaki Arai ,  Satoshi Kurosawa ,  Ko Hasebe ,  Sayoko Kanie ,  Seiichiro Ozono ,  Atsushi Otsuka

发明人： Ryoji Hayashi ,  Tsukasa Kikuchi ,  Masaki Arai ,  Satoshi Kurosawa ,  Ko Hasebe ,  Sayoko Kanie ,  Seiichiro Ozono ,  Atsushi Otsuka

IPC分类号： A61K31/18 ,  C07C307/00 ,  A61P13/00

CPC分类号： C07C311/08

摘要： The benzylamine derivative represented by the formula below and a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical containing the derivative or the pharmaceutically acceptable acid addition salt thereof, and a therapeutic or prophylactic agent for pollakiuria or urinary incontinence containing the derivative or the pharmaceutically acceptable acid addition salt thereof are provided. The benzylamine derivative of the present invention and the pharmaceutically acceptable acid addition salt thereof have less possibility of occurrence of side effects than known compounds, and show a better therapeutic effect against pollakiuria or urinary incontinence, so that they can be used as excellent therapeutic or prophylactic agents for pollakiuria or urinary incontinence.

摘要翻译： 由下式表示的苄胺衍生物及其药学上可接受的酸加成盐，以及含有其衍生物或其药学上可接受的酸加成盐的药物，以及含有该衍生物或药学上可接受的尿酸或尿失禁的治疗或预防剂 提供其酸加成盐。 本发明的苄胺衍生物及其药学上可接受的酸加成盐与已知化合物相比具有较少的副作用的可能性较低，并且对于尿频尿失禁或尿失禁具有较好的治疗效果，因此可用作优异的治疗或预防 尿尿症或尿失禁药物。

公开(公告)号：US20100099769A1

公开(公告)日：2010-04-22

申请号：US12525364

申请日：2008-01-31

申请人： Ryoji Hayashi ,  Tsukasa Kikuchi ,  Masaki Arai ,  Satoshi Kurosawa ,  Ko Hasebe ,  Sayoko Kanie ,  Seiichiro Ozono ,  Atsushi Otsuka

发明人： Ryoji Hayashi ,  Tsukasa Kikuchi ,  Masaki Arai ,  Satoshi Kurosawa ,  Ko Hasebe ,  Sayoko Kanie ,  Seiichiro Ozono ,  Atsushi Otsuka

IPC分类号： A61K31/18 ,  C07C307/00 ,  A61P13/00

CPC分类号： C07C311/08

摘要： The benzylamine derivative represented by the formula below and a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical containing the derivative or the pharmaceutically acceptable acid addition salt thereof, and a therapeutic or prophylactic agent for pollakiuria or urinary incontinence containing the derivative or the pharmaceutically acceptable acid addition salt thereof are provided. The benzylamine derivative of the present invention and the pharmaceutically acceptable acid addition salt thereof have less possibility of occurrence of side effects than known compounds, and show a better therapeutic effect against pollakiuria or urinary incontinence, so that they can be used as excellent therapeutic or prophylactic agents for pollakiuria or urinary incontinence.

摘要翻译： 由下式表示的苄胺衍生物及其药学上可接受的酸加成盐，以及含有其衍生物或其药学上可接受的酸加成盐的药物，以及含有该衍生物或药学上可接受的尿酸或尿失禁的治疗或预防剂 提供其酸加成盐。 本发明的苄胺衍生物及其药学上可接受的酸加成盐与已知化合物相比具有较少的副作用的可能性较低，并且对于尿频尿失禁或尿失禁具有较好的治疗效果，因此可用作优异的治疗或预防 尿尿症或尿失禁药物。