公开(公告)号：US09708237B2

公开(公告)日：2017-07-18

申请号：US14344574

申请日：2012-09-05

申请人： Seong Keun Kim ,  Seung Yang, II ,  Seon Jin Hwang ,  Jung Eun Lee ,  Jong Woo Lee ,  Jun Hee Kang ,  Eun Hak Lim

发明人： Seong Keun Kim ,  Seung Yang, II ,  Seon Jin Hwang ,  Jung Eun Lee ,  Jong Woo Lee ,  Jun Hee Kang ,  Eun Hak Lim

IPC分类号： C07C49/248 ,  C07C49/255 ,  C07H15/207 ,  C09K11/06 ,  C07H15/203 ,  A61K49/00

CPC分类号： C09K11/06 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  C07C49/248 ,  C07C49/255 ,  C07H15/203 ,  C09K2211/1011

摘要： The present invention provides a water-soluble fluorescent compound of resveratrone 6-O-β-glucoside [(E)-4-(8-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)naphthalen-2-yl)but-3-en-2-one] and its derivatives of Formula 1 which have at least one water-soluble substituent, and a method for preparing the same by a photochemical reaction of resveratrol 3-O-β-glucoside and its derivatives of having Formula 3 which are not fluorescent. Said new water-soluble fluorescent compounds has single-photon absorptive characteristics and/or two-photon absorptive characteristics as well as no or little toxicity, and can be usefully utilized in fields that requires water-soluble fluorescent characteristics (diagnosis, fluorescent probe, in vivo imaging, display, etc.).