公开(公告)号：US20240182549A1

公开(公告)日：2024-06-06

申请号：US18284756

申请日：2022-03-31

申请人： Sachdev SIDHU ,  Shane MIERSCH ,  Gang CHEN ,  Jonathan LABRIOLA

发明人： Sachdev SIDHU ,  Shane MIERSCH ,  Gang CHEN ,  Jonathan LABRIOLA

IPC分类号： C07K16/10 ,  C07K14/47

CPC分类号： C07K16/1003 ,  C07K14/4703 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2319/30

摘要： Described herein are peptides and peptide-antibody fusions that bind to the SARS-CoV-2 S protein and the receptor binding domain (RED), and methods for using the compositions containing these antibodies in the treatment of COVID-19, Specifically, we developed novel CoV-2 S protein binding peptides making use of a naïve phage-displayed 16mer peptide library—wherein the CoV-2 S protein binding peptides bind epitopes in both the RBD and S protein outside of the RBD. In addition, we show that fusion of these peptides to the N-terminus of nAbs improves their apparent affinity, potency and breadth of neutralization, without compromising their developability profile, Thus, these peptides represent a novel class of SARS-CoV-2 S protein binders, which can be formatted in various ways to improve functional properties of nAbs to be used in the treatment of many different diseases.