公开(公告)号：US20070281927A1

公开(公告)日：2007-12-06

申请号：US11448597

申请日：2006-06-06

Applicant: Shanthakumar Tyavanagimatt ,  David Fikstad ,  Chandrashekar Giliyar ,  Mahesh Patel ,  Srinivasan Venkateshwaran

Inventor： Shanthakumar Tyavanagimatt ,  David Fikstad ,  Chandrashekar Giliyar ,  Mahesh Patel ,  Srinivasan Venkateshwaran

IPC: A61K31/5415

CPC classification number: A61K31/5415 ,  A61K9/2054 ,  A61K9/4858 ,  A61K9/5084

Abstract: Methods and compositions for delivering a meloxicam compound are disclosed and described. In one aspect, a method may include perorally administering to a subject a therapeutically effective amount of a meloxicam compound that provides a meloxicam plasma concentration within 1 hour which is at least about 40% of the maximum plasma concentration attained by the formulation. In another aspect, a composition may include a therapeutically effective amount of a meloxicam compound in a pharmaceutically acceptable carrier including at least one of an alkalizer or a solubilizer, with the meloxicam compound having a solubility in the carrier that is greater than about 1.0 mg/gm.

Abstract translation: 公开和描述了递送美洛昔康化合物的方法和组合物。 一方面，方法可以包括向受试者口服施用治疗有效量的美洛昔康化合物，所述美洛昔康化合物在1小时内提供美洛昔康血浆浓度，其为制剂达到的最大血浆浓度的至少约40％。 另一方面，组合物可以包括药学上可接受的载体中的治疗有效量的美洛昔康化合物，其包括碱化剂或增溶剂中的至少一种，其中美洛昔康化合物在载体中的溶解度大于约1.0mg / gm。