公开(公告)号：US5543156A

公开(公告)日：1996-08-06

申请号：US184770

申请日：1994-01-21

申请人： Wouter E. Roorda ,  Fred P. Ehnow ,  Estela Basso ,  Karly S. Wang ,  Sharon M. Fujita

发明人： Wouter E. Roorda ,  Fred P. Ehnow ,  Estela Basso ,  Karly S. Wang ,  Sharon M. Fujita

IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K9/10 ,  A61K9/14

CPC分类号： A61K9/204 ,  A61K9/2013 ,  A61K9/7007

摘要： The present invention is directed to erodible delivery devices and to the compositions comprising the devices. The devices comprise (a) a body formed of a bioerodible polymer or polymers together with a required excipient not generally considered to be a pore-former ("required excipient"), and (b) an active agent. The agent is released from the device at a controlled rate and in a therapeutically effective amount, with the rate being primarily independent of the erosion rate of the polymer. The rate of release of the active agent from the polymeric compositions of the present invention is significantly increased over the rate of release dependent on erosion of the polymer matrix. The invention makes possible the increased control over and improved reproducibility of the release profile of the agent from the polymer.The invention is further directed to a method of delivering to an environment of use an active agent, which method comprises placing an appropriately sized and shaped delivery device of the above description in the environment of use.

摘要翻译： 本发明涉及可侵蚀的递送装置和包含该装置的组合物。 所述装置包括（a）由生物可蚀解聚合物或聚合物与通常不被认为是成孔剂（“所需赋形剂”）的所需赋形剂形成的主体，和（b）活性剂。 试剂以受控的速率和治疗有效量从装置释放，速率主要与聚合物的侵蚀速率无关。 活性剂从本发明的聚合物组合物释放的速率相对于依赖于聚合物基质侵蚀的释放速率显着增加。 本发明可以增加对聚合物的药剂释放曲线的控制和改进的再现性。 本发明还涉及一种递送给使用活性剂的环境的方法，该方法包括将上述描述的适当尺寸和形状的输送装置放置在使用环境中。