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公开(公告)号：US08563242B2
公开(公告)日：2013-10-22
申请号：US12833460
申请日：2010-07-09
申请人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Yu Kwan Tong , Shengnan Jin , Siu Chung Stephen Chim , Wai Yi Tsui
发明人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Yu Kwan Tong , Shengnan Jin , Siu Chung Stephen Chim , Wai Yi Tsui
CPC分类号： C12Q1/6827 , C12Q2523/125
摘要： The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy.
摘要翻译： 本发明涉及通过分析来自孕妇的样品来检测染色体非整倍体的新的非侵入性方法。 检测是基于位于与非整倍性相关的染色体上的胎儿甲基化标记的量与位于参考染色体上的胎儿遗传标记的量之间的比例，提供更高的准确度。
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公开(公告)号：US20110039724A1
公开(公告)日：2011-02-17
申请号：US12833460
申请日：2010-07-09
申请人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Yu Kwan Tong , Shengnan Jin , Siu Chung Stephen Chim , Wai Yi Tsui
发明人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Yu Kwan Tong , Shengnan Jin , Siu Chung Stephen Chim , Wai Yi Tsui
CPC分类号： C12Q1/6827 , C12Q2523/125
摘要： The present invention relates to a new, non-invasive method for detecting chromosomal aneuploidy by analyzing a sample from a pregnant woman. The detection is based on the ratio between the amount of a fetal methylation marker located on a chromosome relevant to the aneuploidy and the amount of a fetal genetic marker located on a reference chromosome, offering improved accuracy.
摘要翻译： 本发明涉及通过分析来自孕妇的样品来检测染色体非整倍体的新的非侵入性方法。 检测是基于位于与非整倍性相关的染色体上的胎儿甲基化标记的量与位于参考染色体上的胎儿遗传标记的量之间的比例，提供更高的准确性。
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公开(公告)号：US07901884B2
公开(公告)日：2011-03-08
申请号：US11784499
申请日：2007-04-06
申请人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Shengnan Jin , Tracy Yuen Han Lee , Fiona Miu Fun Lun
发明人： Yuk Ming Dennis Lo , Rossa Wai Kwun Chiu , Stephen Siu Chung Chim , Chunming Ding , Shengnan Jin , Tracy Yuen Han Lee , Fiona Miu Fun Lun
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
摘要翻译： 该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。 更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关 条件。
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公开(公告)号：US20070275402A1
公开(公告)日：2007-11-29
申请号：US11784499
申请日：2007-04-06
申请人： Yuk Lo , Rossa Chiu , Stephen Chim , Chunming Ding , Shengnan Jin , Tracy Lee , Fiona Lun
发明人： Yuk Lo , Rossa Chiu , Stephen Chim , Chunming Ding , Shengnan Jin , Tracy Lee , Fiona Lun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6827 , C12Q2600/154 , C12Q2600/156 , C12Q2523/125
摘要： This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
摘要翻译： 该应用提供了新颖的胎儿标记物用于产前诊断和监测某些妊娠相关病症的用途。 更具体地，本发明在于发现位于胎儿染色体21上的某些CpG岛表现出与位于母体染色体21上的相应CpG岛不同的甲基化谱。该应用还提供用于诊断或监测相关 条件。
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