公开(公告)号：US20070148091A1

公开(公告)日：2007-06-28

申请号：US11610226

申请日：2006-12-13

申请人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

发明人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

IPC分类号： A61K51/00 ,  C07K7/64

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/64 ,  C07K14/521 ,  C07K14/524

摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

公开(公告)号：US20060058240A1

公开(公告)日：2006-03-16

申请号：US11254419

申请日：2005-10-20

申请人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

发明人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

IPC分类号： A61K38/10 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/64 ,  C07K14/521 ,  C07K14/524

摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.