公开(公告)号：US07045636B2

公开(公告)日：2006-05-16

申请号：US10278468

申请日：2002-10-23

申请人： Anandan Palani ,  Sherry A. Shapiro ,  Mark D. McBriar ,  Jing Su

发明人： Anandan Palani ,  Sherry A. Shapiro ,  Mark D. McBriar ,  Jing Su

IPC分类号： C07D207/00 ,  C07D213/00 ,  A01N43/40 ,  A61K31/435

CPC分类号： C07D295/13 ,  A61K38/00 ,  C07C255/60 ,  C07C2601/02 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D295/15 ,  C07K5/06026 ,  C07K5/06139 ,  C07K5/06191

摘要： The present invention discloses compounds, which are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

公开(公告)号：US07345042B2

公开(公告)日：2008-03-18

申请号：US10878788

申请日：2004-06-28

申请人： Anandan Palani ,  Sherry A. Shapiro ,  Hubert B. Josien ,  Thomas A. Bara ,  John W. Clader ,  Pradeep B. Pushpavanam ,  Shengjian Li ,  Mark D. McBriar

发明人： Anandan Palani ,  Sherry A. Shapiro ,  Hubert B. Josien ,  Thomas A. Bara ,  John W. Clader ,  Pradeep B. Pushpavanam ,  Shengjian Li ,  Mark D. McBriar

IPC分类号： A61K31/496 ,  C07D409/14

CPC分类号： C07D409/14

摘要： The present invention discloses methods of using antagonists for melanin-concentrating hormone (MCH), to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes, as well as novel compounds which are antagonists for melanin-concentrating hormone (MCH). In other aspects, the invention is directed to pharmaceutical compositions comprising such MCH antagonists as well as methods for preparing such compounds. Compounds of the invention generally have the structure: where the substituents are as defined herein.

摘要翻译： 本发明公开了使用拮抗剂用于黑色素浓缩激素（MCH），治疗肥胖症，代谢紊乱，进食障碍如食欲过盛和糖尿病的方法，以及作为黑色素浓缩激素（MCH）拮抗剂的新化合物。 在其它方面，本发明涉及包含这种MCH拮抗剂的药物组合物以及制备这些化合物的方法。 本发明的化合物通常具有以下结构：其中取代基如本文所定义。