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    Method for inhibiting cell death, cell death inhibitor, and remedy for disease caused by cell death containing the cell death inhibitor
    1.
    发明申请
    Method for inhibiting cell death, cell death inhibitor, and remedy for disease caused by cell death containing the cell death inhibitor 审中-公开
    用于抑制细胞死亡，细胞死亡抑制剂和由含有细胞死亡抑制剂的细胞死亡引起的疾病的治疗方法

    公开(公告)号：US20060088552A1

    公开(公告)日：2006-04-27

    申请号：US10536797

    申请日：2003-11-27

    申请人： Yasunobu Okada ,  Shigeru Morishima ,  Takashi Nabekura ,  Ken-ichi Manabe ,  Shin-ichiro Mori

    发明人： Yasunobu Okada ,  Shigeru Morishima ,  Takashi Nabekura ,  Ken-ichi Manabe ,  Shin-ichiro Mori

    IPC分类号： A61K39/02

    CPC分类号： A61K38/164

    摘要： A method according to the present invention for inhibiting cell death includes administrating an anion channel-forming peptide to cells under lactacidosis. The anion channel-forming peptide forms an anion channel on a cell membrane artificially. A cell death inhibitor according to the present invention contains the anion channel-forming peptide. Some of examples of the anion channel-forming peptide are a VacA protein derived from Helicobacter pylori and a glycine receptor channel variant peptide. The method and cell death inhibitor according to the present invention are effective especially for necrotic cell death that accompanies cell swelling.

    摘要翻译： 根据本发明的用于抑制细胞死亡的方法包括将阴离子通道形成肽施用于乳酸脱氢酶下的细胞。 阴离子通道形成肽人造细胞膜上形成阴离子通道。 根据本发明的细胞死亡抑制剂含有阴离子通道形成肽。 阴离子通道形成肽的一些实例是来自幽门螺杆菌和甘氨酸受体通道变体肽的VacA蛋白。 根据本发明的方法和细胞死亡抑制剂特别适用于伴随细胞肿胀的坏死细胞死亡。