公开(公告)号：US20070148217A1

公开(公告)日：2007-06-28

申请号：US10579055

申请日：2003-11-12

申请人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

发明人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

IPC分类号： A61K31/4152 ,  A61K9/70

CPC分类号： A61K9/7061 ,  A61K31/4152 ,  C07D231/22 ,  C07D231/26

摘要： A percutaneous absorption type cow protective agent containing as an active ingredient, 0.1 to 30 percent by mass of 3-methyl-1-phenyl-2-pyrazolin-5-one Presented by the following formula: or a medically acceptable salt thereof in a base; a use of the compound as an active ingredient for the manufacture of a percutaneous absorption type pharmaceutical composition for protecting brain; and a method of protecting brain comprising administering to a patient the pharmaceutical composition as an active ingredient,

摘要翻译： 含有作为活性成分的经皮吸收型牛保护剂，0.1〜30质量％的3-甲基-1-苯基-2-吡唑啉-5-酮由下式表示：或其医药上可接受的盐 ; 该化合物作为活性成分用于制造用于保护脑的经皮吸收型药物组合物的用途; 和保护脑的方法，包括向患者施用药物组合物作为活性成分，

公开(公告)号：US08076368B2

公开(公告)日：2011-12-13

申请号：US10579055

申请日：2003-11-12

申请人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

发明人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

IPC分类号： A61K21/4152

CPC分类号： A61K9/7061 ,  A61K31/4152 ,  C07D231/22 ,  C07D231/26

摘要： A percutaneous absorption type cerebral protective agent containing as an active ingredient, 0.1 to 30 percent by mass of 3-methyl-1-phenyl-2-pyrazolin-5-one represented by the following formula: or a medically acceptable salt thereof in a base; a use of the compound as an active ingredient for the manufacture of a percutaneous absorption type pharmaceutical composition for protecting brain; and a method of protecting brain comprising administering to a patient the pharmaceutical composition as an active ingredient.

摘要翻译： 含有作为活性成分的经皮吸收型脑保护剂，0.1〜30质量％的由下式表示的3-甲基-1-苯基-2-吡唑啉-5-酮或其医药上可接受的盐 ; 该化合物作为活性成分用于制造用于保护脑的经皮吸收型药物组合物的用途; 和保护脑的方法，包括向患者施用药物组合物作为活性成分。

公开(公告)号：US5586497A

公开(公告)日：1996-12-24

申请号：US494025

申请日：1995-06-23

申请人： Shingo Shimada

发明人： Shingo Shimada

IPC分类号： B41L13/14 ,  B41L13/06 ,  B41L13/04

CPC分类号： B41L13/06

摘要： A stencil printing machine comprising a cylindrical printing cylinder around which a perforated stencil sheet for mimeographing is wrapped; a stencil sheet storing section for storing a blank stencil for mimeographing; a stencil sheet perforator for perforating a stencil sheet fed from the stencil sheet storing section; a stencil sheet cutter disposed between the stencil sheet perforator and the printing cylinder, for cutting the perforated stencil sheet; a stencil sheet stocking section disposed between the stencil sheet perforator and the stencil sheet cutter, for holding the perforated stencil sheet; a single long member which is mounted, inside the stencil sheet stocking section, in parallel with a direction of width of the stencil sheet, beneath the stencil sheet stocked inside the stencil sheet stocking section, and is vertically movable between the upper limit position and the lower limit position; a driving mechanism for moving the long member up and down; and a stencil sheet feeder for feeding the perforated stencil sheet from the stencil sheet stocking section to the stencil sheet cutter.

摘要翻译： 一种模版印刷机，包括圆柱形印刷滚筒，围绕所述圆柱印刷滚筒包裹用于油印的穿孔模板; 用于存储用于油印的空白模版的模版纸存储部分; 用于对从蜡纸存放部分供给的蜡纸进行穿孔的蜡纸穿孔机; 设置在蜡纸穿孔器和印刷滚筒之间的蜡纸切割机，用于切割穿孔的模板; 设置在模板片穿孔器和蜡纸切割器之间的用于保持穿孔的模板的蜡纸放置部分; 一个长的构件，其被安装在模板放置部分的内部，与蜡纸的宽度方向平行地安装在模版原料存放部分的内部的蜡纸上，并且可以在上限位置和 下限位置 用于上下移动长件的驱动机构; 以及用于将穿孔的蜡纸从模板放置部供给到蜡纸切割器的蜡纸输送器。

公开(公告)号：US20050266062A1

公开(公告)日：2005-12-01

申请号：US10533534

申请日：2002-11-05

申请人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

发明人： Jun Mori ,  Tamaki Horiuchi ,  Seijiro Yama ,  Hitomi Waki ,  Shingo Shimada ,  Hitomi Hashitani

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/4152 ,  A61P9/00

CPC分类号： A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/4152

摘要： The present invention relates to a percutaneous absorption preparation (which may also be in the form of an adhesive preparation) containing, as an active ingredient, 0.1 to 30 percent by mass of 3-methyl-1-phenyl-2-pyrazolin-5-one represented by the following formula: or a medically acceptable salt thereof in an appropriate base such as an aqueous base or a rubber base. This preparation (or adhesive preparation) is an excellent percutaneous absorption preparation (or percutaneous absorption adhesive preparation) which has good percutaneous absorbability of the active ingredient and causes little skin irritation.

摘要翻译： 本发明涉及含有0.1〜30质量％的3-甲基-1-苯基-2-吡唑啉-5-酮的作为活性成分的经皮吸收制剂（其也可以是粘合制剂的形式） 由下式表示的化合物或其药学上可接受的盐在适当的碱如水基或橡胶基中。 该制剂（或粘合剂制剂）是具有良好的经皮吸收性的活性成分的极好的经皮吸收制剂（或经皮吸收性粘合剂制剂），并且几乎不引起皮肤刺激。