公开(公告)号：US20060148844A1

公开(公告)日：2006-07-06

申请号：US10519113

申请日：2003-06-25

申请人： Shinij Nakade ,  Hidehiro Suzuki ,  Hiromu Habashita

发明人： Shinij Nakade ,  Hidehiro Suzuki ,  Hiromu Habashita

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/445 ,  C07D211/48

摘要： A therapeutic and/or preventing agent for a disease due to vascular constriction or vasodilation comprising a EDG-5 modulator. Since EDG-5 modulator specifically binds EDG-5 and shows antagonistic or agonistic action, EDG-5 antagonist is useful for treating and/or preventing for a disease due to vascular constriction, for example, cerebrovascular spasmodic disorder after subarachnoid hemorrhage or stroke, cardiovasucular spasmodic disorder, hypertension, renal disease, cardiac infarction, cardiac angina, arrhythmia, facilitation of the portal blood pressure involved in liver cirrhosis, varicosity involved in liver cirrhosis and the like, or EDG-5 agonist is useful for treating and/or preventing for a disease due to vasodilation of blood vessels, for example, chronic headache (such as migraine, tension-type headache, mixed-type headache thereof, or migrainous neuralgia), haemorrhoid, congestive disorder and the like.

摘要翻译： 由于包含EDG-5调节剂的血管收缩或血管扩张引起的疾病的治疗和/或预防剂。 由于EDG-5调节剂特异性结合EDG-5并且具有拮抗作用或激动作用，因此EDG-5拮抗剂可用于治疗和/或预防由于血管收缩引起的疾病，例如蛛网膜下腔出血或中风后的脑血管性痉挛障碍，心脏血管 痉挛性疾病，高血压，肾脏疾病，心肌梗死，心脏心绞痛，心律失常，肝硬化引起的门静脉血压便利化，参与肝硬化的静脉曲张等，或EDG-5激动剂可用于治疗和/或预防 由于血管血管扩张引起的疾病，例如慢性头痛（如偏头痛，紧张型头痛，混合型头痛或偏头痛神经痛），痔疮，充血性障碍等。