公开(公告)号：US20090291928A1

公开(公告)日：2009-11-26

申请号：US12483846

申请日：2009-06-12

申请人： Shinobu Nishitani ,  Kenji Takehana

发明人： Shinobu Nishitani ,  Kenji Takehana

IPC分类号： A61K31/56 ,  A61K31/198 ,  A61P21/00

CPC分类号： A61K31/198 ,  A23L33/175

摘要： Provided is a composition containing isoleucine, leucine and valine as active ingredients for improving or suppressing side effects associated with a steroid treatment and a composition for suppressing muscular atrophy-related gene. The composition improves or suppresses side effects in a steroid treatment such as muscular atrophy, muscular pain, arthritic pain, impaired glucose tolerance, decreased bone metabolism, impaired immunity, loss of appetite, body weight loss, fatigability and the like, and further suppresses muscular atrophy associated with various diseases. In addition, the composition suppresses muscular atrophy associated with promoted expression of muscular atrophy-related gene associated with glucocorticoid excess or renal failure pathology and the like. Therefore, the composition is effective form improving the QOL of patients.

摘要翻译： 本发明提供含有异亮氨酸，亮氨酸，缬氨酸作为改善或抑制类固醇治疗副作用的有效成分的组合物和抑制肌萎缩相关基因的组合物。 该组合物改善或抑制类固醇治疗中的副作用，例如肌肉萎缩，肌肉疼痛，关节炎疼痛，葡萄糖耐量降低，骨代谢减少，免疫力下降，食欲不振，体重减轻，疲劳等，并进一步抑制肌肉 与各种疾病相关的萎缩。 此外，该组合物抑制与促进与糖皮质激素过量或肾衰竭病理学相关的肌肉萎缩相关基因的表达相关的肌肉萎缩等。 因此，组合物有效地改善了患者的生活质量。

公开(公告)号：US20060205633A1

公开(公告)日：2006-09-14

申请号：US11437578

申请日：2006-05-22

申请人： Shinobu Nishitani ,  Kenji Takehana

发明人： Shinobu Nishitani ,  Kenji Takehana

IPC分类号： A61K38/28 ,  A61K31/198

CPC分类号： A61K45/06 ,  A61K31/198 ,  A61K38/28 ,  A61K2300/00

摘要： A pharmaceutical composition herein provided comprises at least one branched chain amino acid selected from the group consisting of isoleucine, leucine and valine, combined with at least one drug selected from the group consisting of anti-diabetic agents, agents for treating or preventing obesity and agents for treating or preventing diabetic complications. This pharmaceutical composition is useful as an agent for preventing and/or treating diabetes, diabetic complications, hyperinsulinemia, sugar dysbolism, or obesity.

摘要翻译： 本文提供的药物组合物包含至少一种选自异亮氨酸，亮氨酸和缬氨酸的支链氨基酸，与至少一种选自抗糖尿病药，治疗或预防肥胖症和药物的药物组合 用于治疗或预防糖尿病并发症。 该药物组合物可用作预防和/或治疗糖尿病，糖尿病并发症，高胰岛素血症，糖尿病或肥胖症的药剂。